72712-19-7

Upstream product

• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 108-24-7 acetic anhydride 
• 96574-20-8 1-(2,4-diacetoxyphenyl)vinyl acetate 
• 108-46-3 recorcinol 

Downstream Products

• 52751-46-9 3-acetyl-7-hydroxy-2-methyl-chromen-4-one 
• 79889-80-8 2-bromo-1-(2,4-diacetoxy-phenyl)-ethanone 
• 96574-20-8 1-(2,4-diacetoxyphenyl)vinyl acetate 
• 108-58-7 Resorcinol diacetate 
• 127265-10-5 4-ethylresorcinol acetate 
• 52751-42-5 2'-acetoxy-4'-hydroxyacetophenone 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 6320-42-9 7-hydroxy-2-methyl-4H-chromen-4-one 
• 2896-60-8 4-ethyl-1,3-benzenediol 
• 99186-47-7 4-ethyl resorcinol monoacetate 
• 42059-48-3 acetic acid 4-acetyl-3-hydroxyphenyl ester 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF 4-ALKYL RESORCINOL ESTERS

A process for the preparation of one or more esters of 4-alkyl resorcinol comprising the steps of: (i) reacting resorcinol or a pre-cursor thereof with an esterifying agent which comprises at least one of an organic acid, anhydride or chloride having a maximum carbon chain length of 18, at a temperature of 10 to 250 °C; and (ii) reducing the products from step (i) at a pH of 6.5 to 7.5 in the presence of a catalyst in an alcoholic medium.

Acetylation of alcohols, phenols, thiols and amines catalysed by H-beta zeolite

The acetylation of several alcohols, phenols, thiols and amines was effected at room temperature in excellent yields using H-beta zeolite as catalyst and acetic anhydride as acetylating agent under mostly solvent-free conditions.

Electrostatic catalysis by ionic aggregates: Scope and limitations of Mg(ClO4)2 as acylation catalyst

Alkali and alkaline earth metal perchlorates exhibit electrostatic catalysis in the activation of anhydrides for the acylation reaction. Perchlorates with higher values of the charge-size function of the metal ion exhibit better catalytic activity following the order Mg(ClO4) 2>Ba(ClO4)2>LiClO4. Acylation of structurally diverse phenols, thiols, alcohols, and amines have been carried out with stoichiometric amounts of anhydride at room temperature under solvent free conditions in the presence of catalytic amount of Mg(ClO4) 2. Sterically hindered and electron deficient phenols are efficiently acylated. Acylation with sterically hindered anhydrides such as iso-butyric, pivalic, and benzoic anhydrides are carried out with phenols and alcohols in excellent yields. Acid-sensitive alcohols are acylated in excellent yields without any competitive side reactions.

Ac2O-Py/basic alumina as a versatile reagent for acetylations in solvent-free conditions under microwave irradiation

Acetic anhydride-pyridine over basic alumina has been used in order to carry out acetylations of hydroxy, thiol and amino groups in solvent-free conditions under microwave irradiation. The technique can be extended for selective acetylations by regulation of irradiation time.

Novel chemoselective de-esterification of esters of polyacetoxy aromatic acids by lipases

Candida cylindracea lipase (CCL) and porcine pancreatic lipase (PPL) have been used for deacetylation of peracetates of methyl and ethyl esters of six different polyphenolic acids in organic solvents. Exclusive de-esterification of the ester groups derived from the phenolic hydroxy and aliphatic acid over the ester group of the aromatic acid and aliphatic alcohol has been achieved affording the corresponding esters of phenolic acids in as high yields as 90-97%. The results have been corroborated with the mechanism of lipase action.

Photolysis of Enol Acetates and α-Bromo Derivatives of o-(Acyloxy)acetophenones

UV irradiation of enol acetates 3a-g in benzene gives mainly o-(acetoxy)acetophenones 2 and 2-methylchromones 4. Under the same conditions, the dimethyl derivatives 3h and 3i remain unaffected.The α-bromo ketone 5a gives rise to mixtures of o-(acetoxy)acetophenone (2a), the diketone 6, and/or α-acetoxy-o-hydroxyacetophenone (7), depending on the irradiation conditions.The similarities and differences between the two series of experiments, as well as their possible mechanistic implications, are discussed.

Biosynthesis of Aspyrone, a Metabolite of Aspergillus melleus. Incorporation Studies with 14C- and 3H-Labelled Acetates and Malonate

Incorporation studies with 14C-labelled acetates and malonate confirm the polyketide origin of aspyrone (1), and identify the chain starter unit.Five carbons are derived from the methyl group of acetate, and the remaining four from the carboxy group.The pattern of incorporation of tritium from acetate is inconsistent with a biosynthesis from aromatic precursors of the mellein type.Possibly advanced precursors containing a 2-methylchromone nucleus were not incorporated.The evidence suggests that aromatic precursors are not involved in aspyrone biosynthesis, and that the carbon skeleton is produced like that of the co-metabolite asperlactone (6), by decarboxylation and rearrangement of a linear pentaketide intermediate.