72719-14-3

Upstream product

• 10313-60-7 3,4-dimethoxyphenylacetyl chloride 
• 186581-53-3 diazomethane 
• 21618-92-8 (+)-5-(3,4-dihydroxy-benzyl)-dihydro-furan-2-one 
• 2859-78-1 4-Bromoveratrole 
• 10353-53-4 1,2-epoxy-5-hexene 
• 848653-50-9 5-(3-acetoxy-4-methoxy-phenyl)-4-hydroxy-pentanoic acid methyl ester 
• 848653-56-5 4-hydroxy-5-(3-hydroxy-4-methoxy-phenyl)-pentanoic acid 
• 90-05-1 2-methoxy-phenol 
• 613-70-7 2-methoxyphenyl acetate 
• 39716-58-0 pent-4-enoyl chloride 
• 591-80-0 pent-4-enoic acid 
• 818-57-5 Methyl 4-pentenoate 
• 74-88-4 methyl iodide 
• 848653-51-0 5-(3-hydroxy-4-methoxy-benzyl)-dihydro-furan-2-one 

Downstream Products

• 21618-92-8 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone 

Relevant academic research and scientific papers

Concise synthesis of catechin metabolites 5-(30,40-dihydroxyphenyl)-γ-valerolactones (dhpv) in optically pure form and their stereochemical effects on skin wrinkle-reducing activities

A concise and scalable synthetic route for optically pure (4S) and (4R)-5-(30,40-dihydroxyphenyl)-γ-valerolactones (DHPVs), catechin metabolites, has been developed via the efficient construction of a γ-valerolactone moiety from hexe

Novel method for synthesizing DHPV

The present invention relates to a novel synthesis method of DHPV. More specifically, the present invention relates to the novel synthesis method of (5-3andprime;,4andprime;-dihydroxyphenyl)-andgamma;-valerolactone (DHPV) which is a major metabolite of ca

COMPOSITION FOR PREVENTING, IMPROVING OR TREATING PHOTOAGING OF SKIN COMPRISING DHPV

The present invention relates to a photoaging inhibitor, and more specifically it relates to a pharmaceutical composition, a food composition or a cosmetic composition for preventing, improving or treating photoaging of skin, comprising DHPV (5-(3′,4′-Dih

Chemo-, regio- and stereoselective heck arylation of allylated malonates: Mechanistic insights by ESI-MS and synthetic application toward 5-arylmethyl-γ-lactones

We describe herein a general method for the controlled Heck arylation of allylated malonates. Both electron-rich and electron-poor aryldiazonium salts were readily employed as the aryl-transfer agents in good yields and in high chemo-, regio-, and stereoselectivity without formation of decarboxylated byproducts. Reaction monitoring via ESI-MS was used to support the formation of chelated Pd species through the catalytic cycle. Additionally, some Heck adducts were successfully used in the total synthesis of pharmacologically active γ-lactones.

Synthesis and biological activity of the tea catechin metabolites, M4 and M6 and their methoxy-derivatives

Syntheses are reported for metabolites M4 (1) and M6 (2) of the green tea polyphenols epicatechin (EC) and epigallocatechin (EGC) and their gallate derivatives. Several methoxy-derivatives of 1 and 2 were also prepared. Compounds 1 and 2 were evaluated for growth inhibitory activity against a panel of immortalized and malignant human cell lines with 1 being the more active compound. The possible antiinflammatory activity of 1 and its trimethoxy derivative was also evaluated. Neither compound inhibited the release of arachidonic acid, although 1 inhibited NO production by 50% at 20 μM.