72731-58-9

Upstream product

• 112-92-5 1-octadecanol 
• 31081-59-1 1-octadecyl methanesulfonate 
• 1708-40-3 2-phenyl-[1,3]dioxan-5-ol 
• 100-52-7 benzaldehyde 
• 115292-37-0 5-(octadecyloxy)-2-phenyl-1,3-dioxane 

Downstream Products

• 72731-60-3 1-Benzyl-2-octadecyl-rac-glycero-3-phosphocholin 
• 181174-18-5 Toluene-4-sulfonic acid 3-[(3aS,4S,6R,6aS)-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yloxy]-2-octadecyloxy-propyl ester 
• 181174-16-3 Toluene-4-sulfonic acid 3-[(3aS,4R,6R,6aS)-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yloxy]-2-octadecyloxy-propyl ester 
• 181173-67-1 (3aS,4S,6R,6aS)-4-(3-Benzyloxy-2-octadecyloxy-propoxy)-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole 
• 181173-65-9 (3aS,4R,6R,6aS)-4-(3-Benzyloxy-2-octadecyloxy-propoxy)-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole 

Relevant academic research and scientific papers

Synthesis, Physicochemical Characterization, and Self-Assembly of Linear, Dibranched, and Miktoarm Semifluorinated Triphilic Polymers

Linear, dibranched, and miktoarm amphiphiles containing both hydrophobic and fluorophilic moieties were synthesized and characterized in an attempt to elucidate the relationship between semifluorinated amphiphile structure and aggregate behavior in aqueous solution. For the linear and dibranched amphiphiles, there was an exponential decrease in critical aggregation concentration (CMC) and a logarithmic increase in core microviscosity with increasing length of the fluorocarbon segments; while the miktoarm architecture produced no notable trend in microviscosity or CMC. Furthermore, the linear and dibranched surfactants showed enhanced kinetic stability, dissociating more slowly in the presence of human serum than did either the dibranched or miktoarm amphiphiles. Finally, encapsulation studies with the hydrophobic drug paclitaxel (PTX) showed that the ability to solubilize and retain PTX increased with the presence and with the increasing size of the fluorocarbon moiety for both the linear and dibranched amphiphiles, while no such trend was observed for the miktoarm amphiphiles. VC 2014 Wiley Periodicals, Inc.

Parallel synthesis and antileishmanial activity of ether-linked phospholipids

The synthesis and antileishmanial activity of 18 edelfosine analogues are described. Compounds were obtained in parallel combining solid phase and solution phase synthesis. The most active analogue is characterized by the octadecyl group in position 2 of the glycerol chain. Considering that this substitution determines the loss of antitumor activity, a different mechanism of antileishmanial action can be hypothesized.

Anomeric O-alkylation, 15: New 2/1-type surfactants by anomeric O-alkylation of mannofuranose

New 2/1-type surfactants were synthesized from glycerol derivatives 2a-e having a long-chain 2-O-alkyl substituent. Transformation of 2a-d into 1,3-di-O-trifluoromethanesulfonates 4a-d and their use in anomeric O-alkylation of mannofuranose 7 afforded aft