72733-58-5

Upstream product

• 67-66-3 chloroform 
• 104-54-1 3-Phenylpropenol 
• 20615-52-5 (E)-(3-(1-ethoxyethoxy)prop-1-en-1-yl)benzene 
• 57976-72-4 2,2-dichloro-3-phenyl-cyclopropanecarboxaldehyde 

Downstream Products

• 139387-01-2 2-chloro-3-phenylcyclopropanecarboxaldehyde 
• 53646-88-1 1-benzyl-3-phenyl-1H-pyrrole 
• 34266-21-2 1,1-dichloro-t-3-phenylcyclopropane-r-2-carboxylic acid 
• 139387-02-3 (2-Chloro-3-phenyl-cyclopropyl)-methanol 

Relevant academic research and scientific papers

Hydroxamic acid and N-hydroxyurea derivatives and their use

Certain novel hydroxamic acid derivatives having the structure inhibit the enzyme lipoxygenase. These compounds, and the pharmaceutically acceptable salts thereof, are useful in the treatment or alleviation of inflammatory diseases, allergic conditions and cardiovascular diseases in mammals and as the active ingredient in pharmaceutical compositions for treating such conditions.

FORMATION OF 1-SUBSTITUTED PYRROLES IN REACTION OF 2-CHLOROCYCLOPROPANECARBOXALDEHYDES WITH PRIMARY AMINES

Reactions of 2-chlorocyclopropanecarboxaldehydes with primary amines in boiling DMF lead in good yield to 1-substituted pyrroles. 2-Chlorocyclopropanecarboxaldehydes were synthesized by the stereoselective reduction of the corresponding 2,2-dichlorocyclopropanemethanols with lithium tetrahydroaluminate with the subsequent oxidation of the mixture of stereoisomeric 2-chlorocyclopropanemethanols with pyridinium chlorochromate.

REACTION OF DICHLOROCARBENE WITH ALLYL AND CINNAMYL ALCOHOLS

In the reaction of dichlorocarbene, generated by the phase-transfer method, with allyl and cinnamyl alcohols both the products from addition of the dichlorocarbene to the double bond and the products from substitution of the hydroxyl group by a chlorine atom and simultaneous addition of dichlorocarbene at the double bond are formed.