727419-33-2

Upstream product

• 196316-30-0 4,16-dibromo[2.2]paracyclophane 
• 1079-66-9 chloro-diphenylphosphine 

Downstream Products

• 1624314-97-1 rac-4-diphenylphosphino-12-dicyclohexylphosphino[2.2]paracyclophane 
• 727419-41-2 12-bromomethyl-4-diphenylthiophosphino[2.2]paracyclophane 
• 727419-35-4 12-bromomethyl-4-diphenylphosphino[2.2]paracyclophane 
• 727419-34-3 4-diphenylphosphino-12-hydroxymethyl[2.2]paracyclophane 

Relevant academic research and scientific papers

Unsymmetrical bisphosphines for the amidation of aryl chlorides: A kinetic study

The rate-determining step of the palladium-catalyzed amidation of 4-chlorotoluene with benzamide in the presence of unsymmetrical bisphosphines was investigated. Isostructural [2.2]paracyclophane-derived bisphosphines bearing dicyclohexylphosphino and diarylphosphino moieties were investigated as ligands in the oxidative addition and reductive elimination by kinetic studies. The reductive elimination was accelerated when a bisphosphine ligand was applied that contained an electron-rich phosphine group and a less electron-releasing phosphino moiety. Apart from the reductive elimination, the transmetallation had the largest impact on the palladium-catalyzed amidation of aryl halides. Copyright

Synthesis of iridium complexes with new planar chiral chelating phosphinyl-imidazolylidene ligands and their application in asymmetric hydrogenation

The synthesis of planar chiral phosphinoimidazolium salts such as (R p)-3-(4-diphenyl-phosphino[2.2]paracyclophan-12-ylmethyl)-1-(2, 6-diisopropylphenyl)imidazolium bromide (Rp)-11c starting from enantiopure 4,12-dibromo[2.2]paracyclophane (Rp)-6 is reported. After deprotonation of these salts and a subsequent reaction with [Ir(COD)Cl] 2, chelating iridium imidazolylidene complexes (Rp)-5a-c are obtained. These complexes catalyze the asymmetric hydrogenation of functionalized and simple alkenes with up to 89% ee.