72744-55-9 Usage
Uses
Used in Pharmaceutical Industry:
6-Bromo-1,3-benzodioxole-4-carbaldehyde is utilized as a key building block for the development of various pharmaceuticals. Its unique structure and properties allow it to be incorporated into the synthesis of a wide range of therapeutic agents, contributing to the discovery of new drugs and treatment options.
Used in Agrochemical Industry:
In the agrochemical industry, 6-Bromo-1,3-benzodioxole-4-carbaldehyde is employed as a vital component in the synthesis of agrochemicals. Its incorporation into these compounds helps in the development of effective pesticides, herbicides, and other agricultural products that protect crops and enhance agricultural productivity.
Used in Organic Synthesis:
6-Bromo-1,3-benzodioxole-4-carbaldehyde is used as an intermediate in the synthesis of other important chemical compounds. Its reactivity and structural features make it a valuable precursor in the preparation of various organic molecules, facilitating the advancement of organic chemistry.
Used in Drug Discovery Research:
6-Bromo-1,3-benzodioxole-4-carbaldehyde is studied for its potential biological activities, particularly its antifungal and antimicrobial properties. This research is crucial in the identification of new therapeutic agents and the development of novel treatments for various infections and diseases.
Overall, 6-Bromo-1,3-benzodioxole-4-carbaldehyde is a multifaceted chemical compound with diverse applications across different industries, making it an indispensable component in the fields of organic synthesis, medicinal chemistry, and drug discovery research.
Check Digit Verification of cas no
The CAS Registry Mumber 72744-55-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,7,4 and 4 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 72744-55:
(7*7)+(6*2)+(5*7)+(4*4)+(3*4)+(2*5)+(1*5)=139
139 % 10 = 9
So 72744-55-9 is a valid CAS Registry Number.
72744-55-9Relevant academic research and scientific papers
Development of a scalable process for CI-1034, an endothelin antagonist
Jacks, Thomas E.,Belmont, Daniel T.,Briggs, Christopher A.,Horne, Nicole M.,Kanter, Gerald D.,Karrick, Greg L.,Krikke, James J.,McCabe, Richard J.,Mustakis, Jason G.,Nanninga, Thomas N.,Risedorph, Guy S.,Seamans, Ronald E.,Skeean, Richard,Winkle, Derick D.,Zennie, Thomas M.
, p. 201 - 212 (2013/09/04)
A concise, convergent multikilogram synthesis of CI-1034 (1), a potent endothelin receptor antagonist, is described. A 15-step preparation from commercially available o-vanillin and benzenesulfonyl chloride employs a remarkably robust Suzuki coupling between a boronic acid and an aromatic sulfonate ester as the key synthetic step. A scalable route capable of producing multikilogram quantities of CI-1034 with no chromatographic steps is described in this contribution. Improvements to the process included using a 4-fluorobenzenesulfonate ester as a suitable substitute for the triflate group in the Suzuki reaction and the use of MgCl2 as a substitute for TiCl4 in a Dieckmann condensation to provide the benzothiazine dioxide core.
Melanocortin-4 receptor binding compounds and methods of use thereof
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Page 93, (2008/06/13)
Provided are MC4-R binding compounds of the formula XVII: wherein L2 is a linker group, and P1, P2, P3, P4, Z1, Z2, Z3, Z4, Z5, t, s, and R are a
Certain benzothiazine dioxide endothelin antagonists and processes for their preparation
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, (2008/06/13)
The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula 1 The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid hemorrhage.
