72748-33-5

Upstream product

• 1364375-88-1 C₂₂H₃₉NOSi₂ 
• 1364376-55-5 C₁₂H₁₉NO₃ 
• 1364376-58-8 C₁₄H₂₁NO₃S₂ 
• 1364375-77-8 C₁₂H₁₉NO₂ 
• 1364376-65-7 C₉H₁₅N 
• 1364376-68-0 C₁₆H₂₅NOSi 
• 1364375-92-7 2-(2-iodo-1H-indol-3-yl)ethanol 
• 1364375-96-1 C₁₀H₉I₂N 
• 66531-14-4 7-acetyl-2-aza-bicyclo[2.2.2]oct-5-ene-2-carboxylic acid ethyl ester 
• 615-43-0 2-iodophenylamine 
• 81127-39-1 endo-7-ethyl-2-(3-indolylacetyl)-6,6-dimethoxy-2-azabicyclo<2.2.2>octane 
• 38750-13-9 (2-indol-3-yl-ethyl)-carbamic acid benzyl ester 
• 19508-69-1 (+/-)-18-tosyloxy-7-oxo-epiibogamine 
• 81177-00-6 (+/-)-(6-syn)-6-ethyl-2-<2-(3-indolyl)-1-oxoethyl>-7,7-dimethoxy-2-azabicyclo<2.2.2>octane 

Relevant academic research and scientific papers

A novel approach to iboga alkaloids: Total synthesis of (±)-ibogamine and (±)-epi-ibogamine

A novel approach to the total synthesis of (±)-ibogamine and (±)-epi-ibogamine, featuring electrophilic substitution at C(2) of N'-CBZ-tryptamine by an allylic acetate, is described.

Reductive Heck coupling: An efficient approach toward the iboga alkaloids. Synthesis of ibogamine, epiibogamine and iboga analogs

A mild and efficient synthetic route to the iboga scaffold by employing reductive-Heck type annulation is described. The utility of this process is demonstrated by the direct access to the ibogamine, epiibogamine and iboga-analogs. The cyclization precursors were readily obtained from 2-iodoaniline by heteroannulation reaction with suitable alkynes followed by iodination.

1,6-dihydro-3(2H)-pyridinones. X. 2-azabicyclooctane Ring Formation via Intramolecular Michael reaction: Total synthesis of (+/-)-Ibogamine and (+/-)-Epiibogamine

A new elaboration method for the 2-azabicyclooctane ring via an intramolecular Michael reaction has been developed and applied to the total synthesis of (+/-)-ibogamine (1) and (+/-)-epiibogamine (2).The unsaturated estert (9) derived from ethyl 1,

Alkaloid studies. 8. Isolation and characterization of alkaloids of Tabernaemontana heyneana Wall and antifertility properties of coronaridine.

In this study, the roots of Tabernaemontana heyneana Wall were examined and the isolation and identification of additional indole alkaloids and some pharmacological properties of coronaridine are described. Extraction of the roots yielded the alkaloids coronaridine, voacangine, ibogamine, 19-oxocoronaridine, and the pseudoindoxyl of voacangine. An acqueous ethanolic extract of the roots was found to prevent fertilization of adult female rats when administered orally. After the residue of this extract was treated chromatographic fractionation on silica gel yielded the alkaloid coronaridine. When administered to adult female rats, orally, coronaridine hydrochloride at levels of 5 mg/kg/day or above prevented pregnancy. Voacangine, assayed by the same procedure, did not prevent pregnancies. Data indicated that coronaridine was weakly estrogenic.