727652-03-1

Usage

Molecular structure

2-(4-Fluoro-phenyl)-8-methyl-imidazo[1,2-a]-pyridine-3-carbaldehyde has a complex molecular structure that includes a fluoro-phenyl group, a methyl group, and an imidazo-pyridine-3-carbaldehyde moiety.

Heterocyclic and aromatic properties

The presence of an imidazole ring and a pyridine ring in its structure suggests that the compound possesses heterocyclic and aromatic properties.

Potential applications

Due to its structural features, the compound may have potential applications in various fields such as pharmaceuticals, agrochemicals, or materials science.

Further investigation required

The specific uses and properties of the compound would need to be determined through experimentation and analysis, as they are not immediately apparent from its molecular structure alone.

Upstream product

• 1603-40-3 3-methylpyridin-2-ylamine 
• 380873-23-4 2-(4-fluorophenyl)-8-methylimidazo[1,2-a]pyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 403-29-2 2-bromo-4'-fluoroacetophenone 

Downstream Products

• 1423600-00-3 3-(2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl)-1-(4-nitrophenyl)prop-2-en-1-one 
• 1435395-62-2 2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridine-3-carbaldehyde oxime 
• 1435396-87-4 2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridine-3-carbaldehyde-O-[1-(4-cyanobenzyl)-1H-1,2,3-triazol-4-yl]methyl oxime 
• 1435396-80-7 2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridine-3-carbaldehyde-O-[1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl]methyl oxime 
• 1435396-73-8 2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridine-3-carbaldehyde-O-[1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl]methyl oxime 
• 1435396-66-9 2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridine-3-carbaldehyde-O-[1-(4-methylbenzyl)-1H-1,2,3-triazol-4-yl]methyl oxime 
• 1435396-04-5 2-(4-fluorophenyl)-8-methylH-imidazo[1,2-a]pyridine-3-carbaldehyde-O-prop-2-ynyl oxime 
• 1423599-67-0 4-(2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl)-6-phenyl-3,4-dihydropyrimidine-2(1H)-thione 
• 1423599-63-6 6-(4-chlorophenyl)-4-(2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl)-3,4-dihydropyrimidine-2(1H)-thione 
• 1423599-51-2 4-(2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl)-6-phenylpyrimidin-2-amine 
• 1423599-47-6 4-(2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl)-6-p-tolylpyrimidin-2-amine 
• 1423599-43-2 4-(2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl)-6-(4-nitrophenyl)pyrimidin-2-amine 
• 1423599-39-6 4-(4-chlorophenyl)-6-(2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine 
• 1423599-23-8 4-(2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl)-2-methoxy-6-(4-nitrophenyl)nicotinonitrile 

Relevant academic research and scientific papers

Synthesis, Molecular Docking, BSA, and In Vitro Reactivation Study of Imidazopyridine Oximes Against Paraoxon Inhibited Acetylcholinesterase

Aim: To synthesize and evaluate the fused heterocyclic imidazo[1,2-a]pyridine based oxime as a reactivator against paraoxon inhibited acetylcholinesterase. Background: Organophosphorus compounds (OPs) include parathion, malathion, chlorpyrifos, monocrotop

Design, one-pot green synthesis and antimicrobial evaluation of novel imidazopyridine bearing pyran bis-heterocycles

Herein, we report design, one pot synthesis and antibacterial evaluation of novel imidazopyridine bearing pyran bis-heterocycles. The compounds were synthesized in an aqueous solution of gluconic acid under both conventional heating and ultrasound irradiation. The target compounds were obtained in good to moderate yields with yield of 65–88% in 20–60 min under ultrasonic irradiation. The compounds were characterized by spectroscopic methods IR, 1H NMR, 13C NMR, MS and HRMS. X-ray single crystal structure of 7i was also determined. The compounds were evaluated for antibacterial activity by measuring zone of inhibition using disk diffusion method that revealed that some compounds were inhibiting the growth of Gram +ve and Gram -ve bacteria. Result of minimum inhibitory concentration (MIC) showed that 7a, 7h & 7k from a series 7a-7k inhibited the growth of S. aureus. The minimum bactericidal concentration (MBC) value was determined for 7a, 7h & 7k. MBC/MIC ratio of the derivatives 7a, 7k & 7h suggest former two derivatives act as bactericidal agent & later act as bacteriostatic agents against Gram +ve bacteria. Haemolysis results showed that compounds are non-cytotoxic to erythrocytes.

New imidazo[1,2-a]pyridines carrying active pharmacophores: Synthesis and anticonvulsant studies

Five new series of imidazo[1,2-a]pyridines carrying biologically active pyrazoline (4a-e), cyanopyridone (5a, b), cyanopyridine (6a-f), 2-aminopyrimidine (7a-f) and pyrimidine-2-thione (8a-d) systems were designed and synthesized as prominent anticonvulsant agents. The target compounds were screened for their in vivo anticonvulsant activity following maximal electroshock (MES) and subcutaneous pentylene tetrazole (scPTZ) methods at a small test dose of 10 mg/kg. Further, Rotarod toxicity method was used to study the toxicity profile of selected compounds. Compounds 4b, 5a, 5b, 6a, 7e and 8d possessing 4-fluorophenyl substituent at 2nd position of imidazo[1,2-a]pyridine ring displayed potent anticonvulsant activity without displaying any toxicity. Enhanced activity profile was observed for new compounds in PTZ method over MES method.

Facile synthesis of new imidazo[1,2-a]pyridines carrying 1,2,3-triazoles via click chemistry and their antiepileptic studies

The present article reports the synthesis and anticonvulsant studies of new 2-arylimidazo[1,2-a]pyridines carrying suitably substituted 1,2,3-triazoles as well as their intermediates. The structures of newly synthesized compounds were confirmed by various