2-(4-FLUORO-PHENYL)-8-METHYL-IMIDAZO[1,2-A]-PYRIDINE-3-CARBALDEHYDE

Base Information

• Chemical Name: 2-(4-FLUORO-PHENYL)-8-METHYL-IMIDAZO[1,2-A]-PYRIDINE-3-CARBALDEHYDE
• CAS No.: 727652-03-1
• Molecular Formula: C₁₅H₁₁FN₂O
• Molecular Weight: 254.264
• Mol file: 727652-03-1.mol

Synonyms:2-(4-fluorophenyl)-8-methylimidazo[1,2-a]pyridine-3-carbaldehyde

Chemical Property of 2-(4-FLUORO-PHENYL)-8-METHYL-IMIDAZO[1,2-A]-PYRIDINE-3-CARBALDEHYDE

Chemical Property:

Purity/Quality:

98%+ ^*data from raw suppliers

2-(4-Fluorophenyl)-8-methylimidazo[1,2-a]pyridine-3-carbaldehyde 97% ^*data from reagent suppliers

Safty Information:

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Technology Process of 2-(4-FLUORO-PHENYL)-8-METHYL-IMIDAZO[1,2-A]-PYRIDINE-3-CARBALDEHYDE

There total 3 articles about 2-(4-FLUORO-PHENYL)-8-METHYL-IMIDAZO[1,2-A]-PYRIDINE-3-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-(4-fluorophenyl)-8-methylimidazo[1,2-a]pyridine (380873-23-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-(4-fluorophenyl)-8-methylimidazo[1,2-a]pyridine-3-carbaldehyde (727652-03-1)

Guidance literature:

With trichlorophosphate; at 80 ℃; for 6h;

DOI:10.1016/j.bmcl.2012.12.035

Reference yield:

3-methylpyridin-2-ylamine (1603-40-3) → 2-(4-fluorophenyl)-8-methylimidazo[1,2-a]pyridine-3-carbaldehyde (727652-03-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 6 h / Reflux

2: trichlorophosphate / 6 h / 80 °C

With trichlorophosphate; In ethanol;

DOI:10.1016/j.bmcl.2012.12.035

Reference yield:

2-bromo-4'-fluoroacetophenone (403-29-2) → 2-(4-fluorophenyl)-8-methylimidazo[1,2-a]pyridine-3-carbaldehyde (727652-03-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 6 h / Reflux

2: trichlorophosphate / 6 h / 80 °C

With trichlorophosphate; In ethanol;

DOI:10.1016/j.bmcl.2012.12.035

upstream raw materials:

3-methylpyridin-2-ylamine

2-(4-fluorophenyl)-8-methylimidazo[1,2-a]pyridine

N,N-dimethyl-formamide

2-bromo-4'-fluoroacetophenone

Downstream raw materials:

3-(2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl)-1-(4-nitrophenyl)prop-2-en-1-one

2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridine-3-carbaldehyde oxime

2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridine-3-carbaldehyde-O-[1-(4-cyanobenzyl)-1H-1,2,3-triazol-4-yl]methyl oxime

2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridine-3-carbaldehyde-O-[1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl]methyl oxime

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