727662-73-9

Upstream product

• 29289-13-2 2-iodo-4-methylaniline 
• 6967-82-4 2-bromo-5-methylbenzoic acid 
• 1582760-57-3 5-(2-bromo-5-methylphenyl)-3-methyl-1H-pyrazole 
• 446-52-6 2-Fluorobenzaldehyde 
• 90971-88-3 methyl 2-bromo-5-methylbenzoate 

Relevant academic research and scientific papers

CuCl-catalyzed one-pot synthesis of 5,6-dihydropyrazolo[1,5-c]quinazolines

A simple and efficient procedure for the preparation of 5,6-dihydropyrazolo[1,5-c]quinazolines via CuCl-catalyzed tandem reaction of 5-(2-bromoaryl)-1H-pyrazoles with aldehydes and aqueous ammonia under nitrogen atmosphere has been developed. The usefulne

Synthesis of 5,6-dihydropyrazolo[1,5- c ]quinazolines through gold-catalyzed chemoselective bicyclization of N -propargylic sulfonylhydrazones

An efficient method for the preparation of 5,6-dihydropyrazolo[1,5-c]quinazolines via gold(I)-catalyzed chemoselective bicyclization of N-propargylic sulfonylhydrazones has been developed. This process relies on the chemoselective cyclization of the hydrazone nitrogen instead of the usually favored aniline nitrogen onto the alkyne. The synthetic utility of the current strategy is demonstrated through the synthesis of a potential Eg5/Kinesin spindle protein inhibitor.