72778-07-5

Upstream product

• 65750-59-6 2-(4-nitrobenzyloxycarbonylamino)ethanethiol 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 4457-32-3 4-nitrobenzyl chloroformate 
• 67245-93-6 Carbonic acid 4-nitro-benzyl ester 1-((2R,3R)-2-{(E)-2-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-vinyl}-4-oxo-azetidin-3-yl)-ethyl ester 
• 65794-47-0 Carbonic acid 1-[(2S,3R)-2-(2-hydroxy-ethyl)-4-oxo-azetidin-3-yl]-ethyl ester 4-nitro-benzyl ester 
• 72778-03-1 Carbonic acid 4-nitro-benzyl ester 1-[(3R,4S)-2-oxo-4-(2-oxo-ethyl)-azetidin-3-yl]-ethyl ester 
• 65794-50-5 2-Chloro-2-{(2S,3S)-2-{(E)-2-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-vinyl}-3-[1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-malonic acid bis-(4-nitro-benzyl) ester 
• 65750-61-0 2-Hydroxy-2-{(2S,3S)-2-{(E)-2-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-vinyl}-3-[1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-malonic acid bis-(4-nitro-benzyl) ester 
• 65794-49-2 2-{(2S,3S)-2-{(E)-2-[2-(4-Nitro-benzyloxycarbonylamino)-ethylsulfanyl]-vinyl}-3-[1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-malonic acid bis-(4-nitro-benzyl) ester 
• 65750-54-1 (4S,5R,6R)-4-Bromo-3-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-6-[1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-7-oxo-1-aza-bicyclo[3.2.0]heptane-2,2-dicarboxylic acid bis-(4-nitro-benzyl) ester 
• 65794-48-1 Carbonic acid 1-((2S,3R)-2-{2,2-bis-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-ethyl}-4-oxo-azetidin-3-yl)-ethyl ester 4-nitro-benzyl ester 
• 67245-85-6 Bis(p-nitrobenzyl) malonate 
• 65750-58-5 bis(p-nitrobenzyl) ketomalonate 
• 65794-43-6 (5R,6R)-3-[2-(4-Nitro-benzyloxycarbonylamino)-ethylsulfanyl]-6-[(S)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-7-oxo-1-aza-bicyclo[3.2.0]hept-3-ene-2,2-dicarboxylic acid bis-(4-nitro-benzyl) ester 

Downstream Products

• 65991-26-6 (5R,6S)-3-[2-(4-Nitro-benzyloxycarbonylamino)-ethylsulfanyl]-6-[(R)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 

Relevant academic research and scientific papers

Thienamycin Total Synthesis. 3. Total Synthesis of (+/-)-Thienamycin and (+/-)-8-Epithienamycin

The completion of the total synthesis of (+/-)-8-epithienamycin and (+/-)-thienamycin from azetidinones 3a and 3b using the methodology developed for the synthesis of model compound 4 (see part 2) is described.