65991-26-6

Basic information

• Product Name: p-nitrobenzyl (+/-)-cis-3-<2-(p-nitrobenzyloxycarbonylamino)ethylthio>-6β-<(1S^*)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate
• CAS NO: 65991-26-6
• Molecular Weight: 765.711
• Mol File: 65991-26-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: p-nitrobenzyl (+/-)-cis-3-<2-(p-nitrobenzyloxycarbonylamino)ethylthio>-6β-<(1S^*)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: p-nitrobenzyl (+/-)-cis-3-<2-(p-nitrobenzyloxycarbonylamino)ethylthio>-6β-<(1S^*)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate(65991-26-6)
• EPA Substance Registry System: p-nitrobenzyl (+/-)-cis-3-<2-(p-nitrobenzyloxycarbonylamino)ethylthio>-6β-<(1S^*)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate(65991-26-6)

Safety Data

• Hazardous Substances Data: 65991-26-6(Hazardous Substances Data)

Upstream product

• 72789-82-3 (3S,4R)-4-(2,2-dimethoxyethyl)-3-[(1RS)-1-(p-nitrobenzyloxycarbonyloxy)ethyl]-2-oxoazetidine 
• 65750-58-5 bis(p-nitrobenzyl) ketomalonate 
• 65794-48-1 Carbonic acid 1-((2S,3R)-2-{2,2-bis-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-ethyl}-4-oxo-azetidin-3-yl)-ethyl ester 4-nitro-benzyl ester 
• 65794-43-6 (5R,6R)-3-[2-(4-Nitro-benzyloxycarbonylamino)-ethylsulfanyl]-6-[(S)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-7-oxo-1-aza-bicyclo[3.2.0]hept-3-ene-2,2-dicarboxylic acid bis-(4-nitro-benzyl) ester 
• 65750-54-1 (4S,5R,6R)-4-Bromo-3-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-6-[1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-7-oxo-1-aza-bicyclo[3.2.0]heptane-2,2-dicarboxylic acid bis-(4-nitro-benzyl) ester 
• 65794-49-2 2-{(2S,3S)-2-{(E)-2-[2-(4-Nitro-benzyloxycarbonylamino)-ethylsulfanyl]-vinyl}-3-[1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-malonic acid bis-(4-nitro-benzyl) ester 
• 65750-61-0 2-Hydroxy-2-{(2S,3S)-2-{(E)-2-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-vinyl}-3-[1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-malonic acid bis-(4-nitro-benzyl) ester 
• 65794-50-5 2-Chloro-2-{(2S,3S)-2-{(E)-2-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-vinyl}-3-[1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-malonic acid bis-(4-nitro-benzyl) ester 
• 4457-32-3 4-nitrobenzyl chloroformate 
• 76347-45-0 (+/-)-3β-<(1S^*)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-4β-(3-p-nitrobenzyloxycarbonyl-2-oxopropyl)azetidin-2-one 
• 77447-98-4 (+/-)-4β-(2,2-dimethoxyethyl)-3β-<(1S^*)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>azetidin-2-one 
• 77447-99-5 (+/-)-4β-formylmethyl-3β-<(1S^*)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>azetidin-2-one 
• 72447-85-9 cis-3-(1'R^*-hydroxyethyl-4-(2',2'-dimethoxyethyl))-2-azetidinone 
• 76335-76-7 (+/-)-4β-carboxymethyl-3β-<(1S^*)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>azetidin-2-one 

Relevant articles and documents

Azetidinone derivatives, a process for their preparation and their use as intermediates in the preparation of carbapenem antibiotics

Compounds of formula (I): STR1 (wherein R1 represents hydrogen or a hydroxy-protecting group, R2 and R3 represent hydrogen, alkyl or aryl; R4 represents optionally substituted alkyl, alicyclic heterocyclic, aryl

Total Synthesis of (+/-)-Epithienamycins A and B and Derivatives

(+/-)-(3R*,4R*)-4-(2,2-Dimethoxyethyl)-3-*)-1-hydroxyethyl>azetidin-2-one (7), which has been stereoselectively synthesised via the 4-methoxycarbonylisoxazoline (4), was converted into (+/-)-epithienamycins A (2) and B

Thienamycin Total Synthesis. 3. Total Synthesis of (+/-)-Thienamycin and (+/-)-8-Epithienamycin

The completion of the total synthesis of (+/-)-8-epithienamycin and (+/-)-thienamycin from azetidinones 3a and 3b using the methodology developed for the synthesis of model compound 4 (see part 2) is described.