67245-93-6

Upstream product

• 76671-18-6 [(2R,3R)-3-((S)-1-Acetoxy-ethyl)-2-(1-benzenesulfinyl-vinyl)-4-oxo-azetidin-1-yl]-acetic acid tert-butyl ester 
• 76671-17-5 [(2R,3R)-3-((S)-1-Acetoxy-ethyl)-2-(2-chloro-1-phenylsulfanyl-ethyl)-4-oxo-azetidin-1-yl]-acetic acid tert-butyl ester 
• 77363-79-2 <3α(S^*),4β(E)>-3-(1-hydroxyethyl)-4-<2-(2-tritylaminoethyl)thiovinyl>-2-azetidinone 
• 77363-77-0 <3α(S^*),4β(E)>-3-(1-acetoxyethyl)-4-<2-(2-tritylaminoethyl)thiovinyl>-2-azetidinone 
• 77363-76-9 <3α(S^*),4β(E)>-1-tert-butoxycarbonylmethyl-3-(1-acetoxyethyl)-4-<2-(2-tritylaminoethyl)thiovinyl>-2-azetidinone 
• 86531-49-9 [(2R,3R)-3-((S)-1-Acetoxy-ethyl)-2-(1-benzenesulfinyl-2-chloro-ethyl)-4-oxo-azetidin-1-yl]-acetic acid tert-butyl ester 
• 4457-32-3 4-nitrobenzyl chloroformate 
• 65794-42-5 Carbonic acid (R)-1-[(2S,3R)-2-(2-hydroxy-ethyl)-4-oxo-azetidin-3-yl]-ethyl ester 4-nitro-benzyl ester 
• 67314-42-5 Carbonic acid 4-nitro-benzyl ester (R)-1-[(3R,4S)-2-oxo-4-(2-oxo-ethyl)-azetidin-3-yl]-ethyl ester 
• 65750-59-6 2-(4-nitrobenzyloxycarbonylamino)ethanethiol 
• 65750-52-9 Carbonic acid (R)-1-((2S,3R)-2-{2,2-bis-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-ethyl}-4-oxo-azetidin-3-yl)-ethyl ester 4-nitro-benzyl ester 
• 65794-47-0 Carbonic acid 1-[(2S,3R)-2-(2-hydroxy-ethyl)-4-oxo-azetidin-3-yl]-ethyl ester 4-nitro-benzyl ester 
• 72778-03-1 Carbonic acid 4-nitro-benzyl ester 1-[(3R,4S)-2-oxo-4-(2-oxo-ethyl)-azetidin-3-yl]-ethyl ester 
• 65794-48-1 Carbonic acid 1-((2S,3R)-2-{2,2-bis-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-ethyl}-4-oxo-azetidin-3-yl)-ethyl ester 4-nitro-benzyl ester 

Downstream Products

• 65750-60-9 2-Chloro-2-{(2S,3S)-2-{(E)-2-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-vinyl}-3-[(S)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-malonic acid bis-(4-nitro-benzyl) ester 
• 65750-53-0 2-{(2S,3S)-2-{(E)-2-[2-(4-Nitro-benzyloxycarbonylamino)-ethylsulfanyl]-vinyl}-3-[(S)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-malonic acid bis-(4-nitro-benzyl) ester 
• 65750-54-1 (4S,5R,6R)-4-Bromo-3-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-6-[(R)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-7-oxo-1-aza-bicyclo[3.2.0]heptane-2,2-dicarboxylic acid bis-(4-nitro-benzyl) ester 
• 65750-55-2 (5R,6R)-3-[2-(4-Nitro-benzyloxycarbonylamino)-ethylsulfanyl]-6-[(R)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-7-oxo-1-aza-bicyclo[3.2.0]hept-3-ene-2,2-dicarboxylic acid bis-(4-nitro-benzyl) ester 
• 67576-51-6 (5R,6S)-3-[2-(4-Nitro-benzyloxycarbonylamino)-ethylsulfanyl]-6-[(S)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 72778-06-4 (2S,5S,6S)-3-[2-(4-Nitro-benzyloxycarbonylamino)-ethylsulfanyl]-6-[(S)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-7-oxo-1-aza-bicyclo[3.2.0]hept-3-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 72749-11-2 6-Eth-(Z)-ylidene-3-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-7-oxo-1-aza-bicyclo[3.2.0]hept-3-ene-2,2-dicarboxylic acid bis-(4-nitro-benzyl) ester 
• 72765-22-1 6-Eth-(E)-ylidene-3-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-7-oxo-1-aza-bicyclo[3.2.0]hept-3-ene-2,2-dicarboxylic acid bis-(4-nitro-benzyl) ester 
• 65750-61-0 2-Hydroxy-2-{(2S,3S)-2-{(Z)-2-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-vinyl}-3-[(S)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-malonic acid bis-(4-nitro-benzyl) ester 
• 65750-61-0 2-Hydroxy-2-{(2S,3S)-2-{(E)-2-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-vinyl}-3-[(S)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-malonic acid bis-(4-nitro-benzyl) ester 
• 65794-50-5 2-Chloro-2-{(2S,3S)-2-{(E)-2-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-vinyl}-3-[1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-malonic acid bis-(4-nitro-benzyl) ester 
• 65794-49-2 2-{(2S,3S)-2-{(E)-2-[2-(4-Nitro-benzyloxycarbonylamino)-ethylsulfanyl]-vinyl}-3-[1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-malonic acid bis-(4-nitro-benzyl) ester 
• 65750-54-1 (4S,5R,6R)-4-Bromo-3-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-6-[1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-7-oxo-1-aza-bicyclo[3.2.0]heptane-2,2-dicarboxylic acid bis-(4-nitro-benzyl) ester 
• 65794-43-6 (5R,6R)-3-[2-(4-Nitro-benzyloxycarbonylamino)-ethylsulfanyl]-6-[(S)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-7-oxo-1-aza-bicyclo[3.2.0]hept-3-ene-2,2-dicarboxylic acid bis-(4-nitro-benzyl) ester 

Relevant academic research and scientific papers

A STEREOCONTROLLED FORMAL TOTAL SYNTHESIS OF (+/-)-THIENAMYCIN

The stereocontrolled synthesis of a key intermediate 20 for the preparation of (+/-)-thienamycin 1 is described.The key steps in the synthesis are the formation of the β-lactam ring by cyclization of the amide 5 via a complete SN2 mechanism, an

Thienamycin Total Synthesis. 3. Total Synthesis of (+/-)-Thienamycin and (+/-)-8-Epithienamycin

The completion of the total synthesis of (+/-)-8-epithienamycin and (+/-)-thienamycin from azetidinones 3a and 3b using the methodology developed for the synthesis of model compound 4 (see part 2) is described.