728-23-4Relevant articles and documents
Copper-diamine-catalyzed N-arylation of pyrroles, pyrazoles, indazoles, imidazoles, and triazoles
Antilla, Jon C.,Baskin, Jeremy M.,Barder, Timothy E.,Buchwald, Stephen L.
, p. 5578 - 5587 (2004)
This paper details the copper-catalyzed N-arylation of π-excessive nitrogen heterocycles. The coupling of either aryl iodides or aryl bromides with common nitrogen heterocycles (pyrroles, pyrazoles, indazoles, imidazoles, and triazoles) was successfully performed in good yield with catalysts derived from diamine ligands and CuI. General conditions were found that tolerate functional groups such as aldehydes, ketones, alcohols, primary amines, and nitriles on the aryl halide or heterocycle. Hindered aryl halides or heterocycles were also found to be suitable substrates using the conditions reported herein.
Pd- and Cu-catalyzed selective arylation of benzotriazole
Beletskaya, Irina P.,Davydov, Dmitri V.,Moreno-Manas, Marcial
, p. 5617 - 5620 (2007/10/03)
Palladium(0)-catalyzed arylation of 1H-1,2,3-benzotriazole (BTA) in DMF at 150°C in the presence of copper salt with arylhalides proceeds regioselectively at N-1 position. Best result has been obtained with the PdCl2(dppe) as catalyst and the Cu(II) phenylcyclopropylcarboxylate as co- catalyst.