728-49-4Relevant academic research and scientific papers
Stereocontrolled formation of ketomethylene isosteres through tandem chain extension reactions
Lin, Weimin,Tryder, Nancy,Su, Fan,Zercher, Charles K.,Jasinski, Jerry P.,Butcher, Ray J.
, p. 8140 - 8145 (2007/10/03)
A zinc-mediated chain extension reaction is the key step in the preparation of γ-keto amides derived from amino acids. The use of tandem reaction sequences, in which the intermediate zinc enolate is trapped with electrophilic reagents, results in the inco
Acetoacetylation with 2,2,6-Trimethyl-4H-1,3-dioxin-4-one: A Convenient Alternative to Diketene.
Clemens, Robert J.,Hyatt, John A.
, p. 2431 - 2435 (2007/10/02)
The diketene/acetone adduct, 2,2,6-trimethyl-4H-1,3-dioxin-4-one, efficiently acetoacetylates aliphatic and aromatic alcohols, amines, and thiols.These acetoacetylation reactions are fast and stoichiometric, require no catalysis, and give only volatile byproducts.
