72801-90-2

Upstream product

• 83844-78-4 1-<<3-(2-guanidino-4-thiazolyl)phenyl>amino>-1-(methylthio)-2-nitroethene 
• 74-89-5 methylamine 
• 72801-60-6 2-guanidino-4-(3-aminophenyl)thiazole 
• 83831-32-7 2-guanidino-4-(3-nitrophenyl)thiazole 
• 2227-64-7 3'-nitro-2-bromoacetophenone 

Relevant academic research and scientific papers

Conformational requirements for histamine H2-receptor inhibitors: A structure-activity study of phenylene analogues related to cimetidine and tiotidine

Two series of compounds related to cimetidine and tiotidine were synthesized as part of a study to evaluate the importance of conformational parameters in binding at histamine H2 receptors. The flexible methylthioethyl connecting chain was repl

Antisecretory guanidine derivatives and pharmaceutical compositions containing them

The guanidine derivative has the formula: STR1 where X is O or S: Y is N, CH or CCH3 : m is 0 or 1: R1 is hydrogen and R2 cyano, trifluoroacetyl, C1-6 alkanoyl, 4,5-dihydro-4-oxothiazol-2-yl or A-B where A is 3,4-dioxocyclobutene-1,2-diyl or C=Z where Z is oxygen, sulphur, NCN, NNO2, CHNO2, NCONH2, C(CN)2, NCOR6, NCO2 R6, NSO2 R6 or NR7 where R6 is C1-6 alkyl and R7 is hydrogen or C1-6 alkyl and B is C1-6 alkyl, alkoxy or alkylthio or NR8 R9 where R8 and R9 are hydrogen, C1-10 alkyl, C3-10 -alkenyl, alkynyl or alkoxyalkyl, C2-6 (primary hydroxy)alkyl, or, when R9 is hydrogen, R8 is 2-[[5-dimethylaminomethylfuran-2-yl]methylthio]-ethylamino or R8 and R9 are together a 5- or 6-membered non-aromatic ring optionally containing an additional N or O; or R1 and R2 are together imidazolidin-2-ylidene: R3 is hydrogen or fluorine: R4 is halogen or methyl: R5 is hydrogen, C1-6 alkyl or C3-10 alkoxyalkyl: and the salts thereof.