728034-24-0

Usage

Uses

Used in Conjugation Chemistry:
NHS-BiB is used as an ATRP initiator for the synthesis of polymers with specific functionalities. Its NHS ester moiety enables efficient conjugation to various biomolecules, such as peptides, proteins, and antibodies, facilitating the development of bioconjugates for various applications.
Used in Drug Delivery Systems:
In the pharmaceutical industry, NHS-BiB is used as a component in the design and synthesis of drug delivery systems. Its ability to form stable covalent bonds with biological molecules allows for the development of targeted drug delivery systems, improving the therapeutic efficacy and reducing side effects of drugs.
Used in Biomaterials and Tissue Engineering:
NHS-BiB is also utilized in the field of biomaterials and tissue engineering. Its conjugation chemistry properties enable the development of biofunctional materials with specific biological activities, such as cell adhesion, growth factor presentation, and controlled drug release, contributing to the advancement of tissue regeneration and repair strategies.

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 20769-85-1 2-bromoisobutyric acid bromide 
• 2052-01-9 2-bromo-2-methylpropionic acid 

Downstream Products

• 1509929-70-7 3-(2-bromo-2-methylpropanamido)-3-(2-nitrophenyl)propanoic acid 

Relevant academic research and scientific papers

A covalent-chemistry approach to giant macromolecules and their wetting behavior on solid substrates

Hair raising! Poly(methyl methacrylate) chains grown on a dendronized polymer (denpol) having repeat units with terminal 2-bromoisobutyramide groups produce a hairy surface. When adsorbed on mica, MoS2, and highly oriented pyrolytic graphite, the hairy denpol molecules have a quasi two dimensional backbone conformation. The 50-nm-long hairs bend back on the MoS2 (see image) and graphite substrates.

A new approach to bioconjugates for proteins and peptides ( pegylation ) utilising living radical polymerisation

The synthesis of protein-polymer bioconjugates is reported using N-succinimidyl ester functionalised polymers from transition metal mediated living radical polymerisation.

A novel electrochemiluminescence immunosensor via polymerization-assisted amplification

A novel electrochemiluminescent immunosensor with polymerization-assisted signal amplification has been developed and enhanced sensitivity was achieved by increasing tertiary amine loading on polymers. The Royal Society of Chemistry.

PROTEIN-POLYMER CONJUGATES AND METHODS FOR THEIR PREPARATION

This document relates to materials and methods for using controlled radical polymerization (e.g., atom transfer radical polymerization) to generate protein-polymer conjugates in which two or more polymer molecules are attached to individual initiator molecules on the protein.

Fast and efficient [2 + 2] UV cycloaddition for polymer modification via flow synthesis

The alkene-enone [2 + 2] photocycloaddition reaction between polymer-bound maleimide and functional alkenes has been tested in a UV-flow reactor, demonstrating a very high efficiency of the reaction. As a test reaction, polymer end group modifications were carried out on maleimide-functional poly(butyl acrylate). The polymer was prepared by atom transfer radical polymerization (ATRP) using a N-hydroxysuccinimide-functionalized initiator, followed by exchange reaction of the activated ester with a maleimide amine linker. Good control over the polymerization and successful exchange of the end group under mild reaction conditions was confirmed by electrospray ionization mass spectrometry (ESI-MS). The terminal maleimide group was then reacted quantitatively with alkenes in a custom-made tubular UV-flow reactor within a minute reaction time. Compared to reaction times in batch of several hours to days, the reaction proceeds to full conversion within 1 min under flow conditions. This significant acceleration of the reaction was achieved by employing a photosensitizer in combination with the flow reactor technique. Via the cycloaddition a variety of functional groups can be introduced to the polymer chain ranging from multifunctional allyl compounds to hydroxyl-functional alkenes, demonstrating the general versatility and high potential of the approach for polymer modification reactions.

ACRYLOYLOXYETHYLPHOSPHORYLCHOLINE CONTAINING POLYMER CONJUGATES AND THEIR PREPARATION

The present invention relates to polymeric reagents and conjugates thereof, methods for synthesizing the polymeric reagents and conjugates, pharmaceutical compositions comprising the conjugates and methods of using the polymer conjugates including therapeutic methods where conjugates are administered to patients.