72806-61-2

Basic information

• Product Name: 1-(5-CHLORO-2-METHYLPHENYL)-2-THIOUREA
• Synonyms: 1-(5-CHLORO-2-METHYLPHENYL)-2-THIOUREA;N-(5-CHLORO-2-METHYLPHENYL)THIOUREA
• CAS NO: 72806-61-2
• Molecular Formula: C₈H₉ClN₂S
• Molecular Weight: 200.69
• Mol File: 72806-61-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 160 °C
• Boiling Point: 305.9°C at 760 mmHg
• Flash Point: 138.8°C
• Appearance: /
• Density: 1.376g/cm³
• Vapor Pressure: 0.0008mmHg at 25°C
• Refractive Index: 1.7
• CAS DataBase Reference: 1-(5-CHLORO-2-METHYLPHENYL)-2-THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-CHLORO-2-METHYLPHENYL)-2-THIOUREA(72806-61-2)
• EPA Substance Registry System: 1-(5-CHLORO-2-METHYLPHENYL)-2-THIOUREA(72806-61-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 72806-61-2(Hazardous Substances Data)

Usage

General Description

1-(5-CHLORO-2-METHYLPHENYL)-2-THIOUREA is a chemical compound with the molecular formula C8H8ClN3S. It is a thiourea derivative, which is a group of organosulfur compounds with the general structure R1R2NC(S)NR3R4. This particular compound features a 5-chloro-2-methylphenyl group attached to the thiourea functional group. Thioureas have been studied for a variety of potential applications, including as catalysts in organic reactions and as pharmaceutical agents. The specific properties and potential uses of 1-(5-CHLORO-2-METHYLPHENYL)-2-THIOUREA may depend on factors such as its purity, concentration, and chemical interactions.

InChI:InChI=1/C8H9ClN2S/c1-5-2-3-6(9)4-7(5)11-8(10)12/h2-4H,1H3,(H3,10,11,12)

Upstream product

• 1147550-11-5 ammonium thiocyanate 
• 95-79-4 5-chloro-2-methyl-benzenamine 
• 540-72-7 sodium thiocyanide 
• 82635-63-0 1-(5-Chloro-2-methylphenyl)-3-benzoyl-2-thiourea 
• 19241-36-2 5-chloro-2-methylphenylisothiocyanate 

Downstream Products

• 82635-69-6 N-(2-chloro-5-methylphenyl)-S-methylisothiourea 
• 88884-45-1 1-(5-Chloro-2-methyl-phenyl)-2-methyl-isothiourea; hydriodide 
• 302841-04-9 1-(5-chloro-2-methyl-phenyl)-2-ethyl-isothiourea 
• 141857-53-6 2-Amino-6-chloro-3-methyl-benzenethiol 
• 82635-94-7 2-[3-(5-Chloro-2-methyl-phenyl)-2-methyl-isothioureidomethylene]-malonic acid diethyl ester 
• 82636-22-4 1-(5-Chloro-2-methyl-phenyl)-2-methylsulfanyl-6-oxo-1,6-dihydro-pyrimidine-5-carboxylic acid ethyl ester 
• 88884-60-0 N-(5-Chloro-2-methyl-phenyl)-morpholine-4-carboxamidine; hydriodide 
• 88884-59-7 N-(5-Chloro-2-methyl-phenyl)-pyrrolidine-1-carboxamidine; hydriodide 
• 302840-81-9 1-(5-chloro-2-methyl-phenyl)-2-ethylsulfanyl-1H-imidazole-4,5-dione 
• 78584-09-5 4-methyl-7-chloro-2-aminobenzothiazole 

Relevant articles and documents

Design, synthesis and antimicrobial study of novel 1-(1,3-benzothiazol-2-yl)-3-chloro-4H-spiro[azetidine-2,3'-indole]-2',4(1'H)-diones through ketene–imine cycloaddition reaction

The present study deals with the synthesis of novel 1-(1,3-benzothiazol-2-yl)-3-chloro-4H-spiro[azetidine-2,3'-indole]-2',4(1'H)-dione derivatives from the reaction of 3-(1,3-benzothiazol-2-ylimino)-1,3-dihydro-2H-indol-2-one derivatives with chloroacetyl chloride in the presence of triethyl-amine (TEA). The mechanism involved simple acid or base catalysed reaction through the formation of Schiff base followed by cyclisation via ketene–imine cycloaddition reaction. All synthesized compounds were characterized by FT-IR,1H-NMR,13C-NMR, and elemental analysis. The antimicrobial activities of the synthesized derivatives 5a-5g were examined via Micro Broth Dilution method against bacterial strains Bacillius subtilis, Staphylcoccus aureus, E. coli, P. aeruginosa, and fungal strain Candida albicans for determining MIC values. Ampicillin, chloramphenicol, and griseofulvin were used as standard drugs. The MIC values for antimicrobial activity of synthesized compounds were examined using Micro Broth Dilution method. Compounds 5a, 5b, and 5c were found effective against E. coli (MTCC 442) and P.aeruginosa (MTCC 441) and all compounds showed moderate to excellent activity against Streptococcus aureus (MTCC 96) and Bacillius subtilis (MTCC 441). Regarding the antifungal screening, compounds 5a, 5b, and 5c exhibited excellent activity against Candida albicans MTCC 227. 1-(1,3-benzothiazol-2-yl)-3-chloro-4H-spiro[azetidine-2,3'-indole]-2',4(1'H)-dione derivatives may be used as potential lead molecules as effective antimicrobial agents.

Synthesis and antimicrobial activity of structurally flexible heterocycles with the 1,4-thiazine heterosystem

In this work, 4H-1,4-benzothiazines were synthesized by an efficient synthetic method in a single step involving heterocyclization of substituted 2-aminobenzenethiols with β-ketoester. The structures of the synthesized compounds were confirmed by their analytical and spectral data. The synthesized compounds were evaluated for their antimicrobial activity against bacterial species; E. coli and Bacillus cereus. The synthesized compounds showed significant activity against microorganisms, which can be correlated with the privileged heterocyclic structural scaffolds.

Effects of 2-(substituted-sulfanyl)-3,5-dihydro-imidazole-4-one and 2-(Substituted-sulfanyl)-1H-imidazole-4,5-dione derivatives on serum HDL-cholesterol

A series of 2-substituted sulfanyl-3,5-dihydro-imidazole-4-ones and 2-substituted sulfanyl-1H-imidazole-4,5-diones was prepared and shown to increase high density lipoprotein cholesterol over other lipid fractions. Compound 1f showed efficacy in additional animal models. The major metabolite of 1f was isolated and its synthesis is reported. The effects of the metabolite on the lipid profile in rats were investigated. (C) 2000 Elsevier Science Ltd. All rights reserved.