72806-61-2

Usage

Uses

Since the provided materials do not specify the exact applications of 1-(5-CHLORO-2-METHYLPHENYL)-2-THIOUREA, the following uses are inferred based on the general properties of thiourea derivatives:
Used in Pharmaceutical Industry:
1-(5-CHLORO-2-METHYLPHENYL)-2-THIOUREA may be used as a pharmaceutical agent for [specific medical condition or therapeutic purpose] due to its potential biological activity and chemical structure that allows for interactions with biological targets.
Used in Chemical Catalysts:
In the chemical industry, 1-(5-CHLORO-2-METHYLPHENYL)-2-THIOUREA could be employed as a catalyst in organic reactions for [specific type of reaction or process], leveraging its ability to facilitate or enhance the reaction rate.

InChI:InChI=1/C8H9ClN2S/c1-5-2-3-6(9)4-7(5)11-8(10)12/h2-4H,1H3,(H3,10,11,12)

Upstream product

• 19241-36-2 5-chloro-2-methylphenylisothiocyanate 
• 1147550-11-5 ammonium thiocyanate 
• 95-79-4 5-chloro-2-methyl-benzenamine 
• 540-72-7 sodium thiocyanide 
• 82635-63-0 1-(5-Chloro-2-methylphenyl)-3-benzoyl-2-thiourea 

Downstream Products

• 82635-69-6 N-(2-chloro-5-methylphenyl)-S-methylisothiourea 
• 88884-45-1 1-(5-Chloro-2-methyl-phenyl)-2-methyl-isothiourea; hydriodide 
• 88884-59-7 N-(5-Chloro-2-methyl-phenyl)-pyrrolidine-1-carboxamidine; hydriodide 
• 88884-60-0 N-(5-Chloro-2-methyl-phenyl)-morpholine-4-carboxamidine; hydriodide 
• 141857-53-6 2-Amino-6-chloro-3-methyl-benzenethiol 
• 82635-94-7 2-[3-(5-Chloro-2-methyl-phenyl)-2-methyl-isothioureidomethylene]-malonic acid diethyl ester 
• 82636-22-4 1-(5-Chloro-2-methyl-phenyl)-2-methylsulfanyl-6-oxo-1,6-dihydro-pyrimidine-5-carboxylic acid ethyl ester 
• 302840-81-9 1-(5-chloro-2-methyl-phenyl)-2-ethylsulfanyl-1H-imidazole-4,5-dione 
• 302841-04-9 1-(5-chloro-2-methyl-phenyl)-2-ethyl-isothiourea 
• 78584-09-5 4-methyl-7-chloro-2-aminobenzothiazole 

Relevant academic research and scientific papers

Design, synthesis and antimicrobial study of novel 1-(1,3-benzothiazol-2-yl)-3-chloro-4H-spiro[azetidine-2,3'-indole]-2',4(1'H)-diones through ketene–imine cycloaddition reaction

The present study deals with the synthesis of novel 1-(1,3-benzothiazol-2-yl)-3-chloro-4H-spiro[azetidine-2,3'-indole]-2',4(1'H)-dione derivatives from the reaction of 3-(1,3-benzothiazol-2-ylimino)-1,3-dihydro-2H-indol-2-one derivatives with chloroacetyl chloride in the presence of triethyl-amine (TEA). The mechanism involved simple acid or base catalysed reaction through the formation of Schiff base followed by cyclisation via ketene–imine cycloaddition reaction. All synthesized compounds were characterized by FT-IR,1H-NMR,13C-NMR, and elemental analysis. The antimicrobial activities of the synthesized derivatives 5a-5g were examined via Micro Broth Dilution method against bacterial strains Bacillius subtilis, Staphylcoccus aureus, E. coli, P. aeruginosa, and fungal strain Candida albicans for determining MIC values. Ampicillin, chloramphenicol, and griseofulvin were used as standard drugs. The MIC values for antimicrobial activity of synthesized compounds were examined using Micro Broth Dilution method. Compounds 5a, 5b, and 5c were found effective against E. coli (MTCC 442) and P.aeruginosa (MTCC 441) and all compounds showed moderate to excellent activity against Streptococcus aureus (MTCC 96) and Bacillius subtilis (MTCC 441). Regarding the antifungal screening, compounds 5a, 5b, and 5c exhibited excellent activity against Candida albicans MTCC 227. 1-(1,3-benzothiazol-2-yl)-3-chloro-4H-spiro[azetidine-2,3'-indole]-2',4(1'H)-dione derivatives may be used as potential lead molecules as effective antimicrobial agents.

OPIOID RECEPTOR MODULATORS AND USE THEREOF

Disclosed is an in vitro screening method for identifying an antagonist-to-agonist allosteric modifier of a mu-opioid receptor and an in vivo method for confirming that a test compound is such a modifier of a mu-opioid receptor. Also disclosed is a method

Synthesis and antimicrobial activity of structurally flexible heterocycles with the 1,4-thiazine heterosystem

In this work, 4H-1,4-benzothiazines were synthesized by an efficient synthetic method in a single step involving heterocyclization of substituted 2-aminobenzenethiols with β-ketoester. The structures of the synthesized compounds were confirmed by their analytical and spectral data. The synthesized compounds were evaluated for their antimicrobial activity against bacterial species; E. coli and Bacillus cereus. The synthesized compounds showed significant activity against microorganisms, which can be correlated with the privileged heterocyclic structural scaffolds.

Therapeutic modulation of PPARgamma activity

Modulators of PPARγ activity are used in methods of treating and/or preventing conditions such as osteoporosis, Alzheimer's disease, psoriasis and acne, and cancer.

Effects of 2-(substituted-sulfanyl)-3,5-dihydro-imidazole-4-one and 2-(Substituted-sulfanyl)-1H-imidazole-4,5-dione derivatives on serum HDL-cholesterol

A series of 2-substituted sulfanyl-3,5-dihydro-imidazole-4-ones and 2-substituted sulfanyl-1H-imidazole-4,5-diones was prepared and shown to increase high density lipoprotein cholesterol over other lipid fractions. Compound 1f showed efficacy in additional animal models. The major metabolite of 1f was isolated and its synthesis is reported. The effects of the metabolite on the lipid profile in rats were investigated. (C) 2000 Elsevier Science Ltd. All rights reserved.

Improved Procedures for the Preparation of Cycloalkyl-, Arylalkyl-, and Arylthioureas

An improved procedure for the preparation of arylthioureas consists of the reaction of benzoyl isothiocyanate with anilines in acetone and debenzoylation of the resultant N-aryl-N'-benzoylthioureas with 5percent aqueous sodium hydroxide.Bicycloalkylthioureas and N-(arylalkyl)thioureas (e.g. 9H-9-fluorenylthiourea) are directly prepared from the corresponding isothiocyanates and ammonia.

Synthesis & Pharmacological Evaluation of Ethyl 3-Substituted-phenyl-2-methylmercapto/ phenyl/ methyl-4(3H)-pyrimidone-5-carboxylates

A number of ethyl 3-substituted-phenyl-2-methylmercapto/ phenyl/ methyl-4(3H)-pyrimidone-5-carboxylates (V) have been prepared by the reaction of amidines (III) with diethyl ethoxymethylenemalonate.In order to confirm the structure (V), ethyl 3-(2'-methylphenyl)-2-methylmercapto-4(3H)pyrimidone-5-carboxylate (103) has been transformed into the earlier synthesised 3-(2'-methylphenyl)-2-methylmercapto-4(3H)-pyrimidone (115) by decarboxylation of 3-(2'-methylphenyl)-2-methylmercapto-4(3H)-pyrimidone-5-carboxylic acid (114), obtained by the alkaline hydrolysis of 103.Someof these compounds have shown antiinflammatory, diuretic and antipassive cutaneous anaphylaxis activities.