7287-51-6

Upstream product

• 7287-40-3 ethyl 5-hydroxy-2-methyl-benzofuran-3-carboxylate 
• 77-78-1 dimethyl sulfate 
• 72796-47-5 8,8-Dimethoxy-3-methyl-6-oxo-2-oxa-bicyclo[3.2.1]oct-3-ene-4-carboxylic acid ethyl ester 
• 4897-68-1 2-iodo-4-methoxybromobenzene 
• 141-97-9 ethyl acetoacetate 
• 106-51-4 p-benzoquinone 
• 74-88-4 methyl iodide 
• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 
• 2009-97-4 ethyl 2-diazo-3-oxobutanoate 

Downstream Products

• 29735-88-4 5-methoxy-2-methylbenzofuran-3-carboxylic acid 
• 1966107-70-9 C₂₄H₂₅F₃N₂O₃ 

Relevant academic research and scientific papers

Synthesis method 4 -cycloheximide methyl substituted benzofuran derivative

The invention provides a synthesis method of 4 - cycloheximide methyl substituted benzofuran derivatives. Belong to organic synthesis technical field. After the Lewis-methyl benzofuran 5 - carboxylic acid is obtained -2 -methoxy -3 -methylbenzofuran 5 - carboxylic acid and then subjected to a hydrolysis reaction under basic conditions to obtain -2 -methoxy -3 -methylbenzofuran 5 - carboxylic acid, and then reacted with -2 - aniline in the presence of a condensing agent and a base to obtain -3 -methoxy R - methyl 5 -2 - R -phenyl benzofuran -3 - N formamide. After demethyl reaction 5 - hydroxyl -2 - methyl - N-R -phenyl benzofuran -3 - formamide was obtained, and finally, formaldehyde was added. Of the cycloheximide Mannich resulted in the final product.

Controllable Rh(III)-Catalyzed Annulation between Salicylaldehydes and Diazo Compounds: Divergent Synthesis of Chromones and Benzofurans

A Rh(III)-catalyzed annulation between salicylaldehydes and diazo compounds with controllable chemoselectivity is described. AgNTf2 favored benzofurans via a tandem C-H activation/decarbonylation/annulation process, while AcOH led to chromones through a C-H activation/annulation pathway. The reaction exhibited good functional group tolerance and scalability. Moreover, only a single regioisomer of benzofuran was obtained due to the in situ decarbonylation orientation effect.

CuI-catalyzed domino process to 2,3-disubstituted benzofurans from 1-bromo-2-iodobenzenes and β-keto esters

(Chemical Equation Presented) CuI-catalyzed coupling of 1-bromo-2-iodobenzenes with β-keto esters in THF at 100°C leads to 2,3-disubstituted benzofurans. This domino transformation involves an intermolecular C-C bond formation and a subsequent intramolecular C-O bond formation process. Benzofurans with different substituents at the 5- and 6-position are accessible by employing the corresponding 1-bromo-2-iodobenzenes.

Regiospecific Nucleophilic Aromatic Substitution: Conjugate Addition of Active Methylene Compounds to Quinone Monoacetals and Aromatization of the Adducts

Diethyl malonate adds to a variety of quinone monoacetals in a Michael reaction; acid-catalyzed loss of methanol and enolization converts the adducts to hydroquinone monoethers substituted ortho to the alkoxy substituent.The same sequence applied to ethyl