7287-51-6Relevant articles and documents
Synthesis method 4 -cycloheximide methyl substituted benzofuran derivative
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, (2021/11/27)
The invention provides a synthesis method of 4 - cycloheximide methyl substituted benzofuran derivatives. Belong to organic synthesis technical field. After the Lewis-methyl benzofuran 5 - carboxylic acid is obtained -2 -methoxy -3 -methylbenzofuran 5 - carboxylic acid and then subjected to a hydrolysis reaction under basic conditions to obtain -2 -methoxy -3 -methylbenzofuran 5 - carboxylic acid, and then reacted with -2 - aniline in the presence of a condensing agent and a base to obtain -3 -methoxy R - methyl 5 -2 - R -phenyl benzofuran -3 - N formamide. After demethyl reaction 5 - hydroxyl -2 - methyl - N-R -phenyl benzofuran -3 - formamide was obtained, and finally, formaldehyde was added. Of the cycloheximide Mannich resulted in the final product.
CuI-catalyzed domino process to 2,3-disubstituted benzofurans from 1-bromo-2-iodobenzenes and β-keto esters
Lu, Biao,Wang, Bao,Zhang, Yihua,Ma, Dawei
, p. 5337 - 5341 (2008/02/07)
(Chemical Equation Presented) CuI-catalyzed coupling of 1-bromo-2-iodobenzenes with β-keto esters in THF at 100°C leads to 2,3-disubstituted benzofurans. This domino transformation involves an intermolecular C-C bond formation and a subsequent intramolecular C-O bond formation process. Benzofurans with different substituents at the 5- and 6-position are accessible by employing the corresponding 1-bromo-2-iodobenzenes.