1966107-70-9Relevant academic research and scientific papers
Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex
Calabrese, David R.,Hewitt, William M.,Alden, Stephanie,Hilimire, Thomas A.,Saunders, Lindsey B.,Schneekloth, John S.,Chen, Xiang,He, Fahu,Walters, Kylie J.,Leon, Elena C.,Gaikwad, Snehal M.,Phyo, Zaw,Michalowski, Aleksandra M.,Simmons, John K.,Zhang, Shuling,Connors, Daniel,Mock, Beverly A.
, (2018)
G-quadruplexes (G4s) are noncanonical DNA structures that frequently occur in the promoter regions of oncogenes, such as MYC, and regulate gene expression. Although G4s are attractive therapeutic targets, ligands capable of discriminating between differen
Synthesis method 4 -cycloheximide methyl substituted benzofuran derivative
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, (2021/11/27)
The invention provides a synthesis method of 4 - cycloheximide methyl substituted benzofuran derivatives. Belong to organic synthesis technical field. After the Lewis-methyl benzofuran 5 - carboxylic acid is obtained -2 -methoxy -3 -methylbenzofuran 5 - carboxylic acid and then subjected to a hydrolysis reaction under basic conditions to obtain -2 -methoxy -3 -methylbenzofuran 5 - carboxylic acid, and then reacted with -2 - aniline in the presence of a condensing agent and a base to obtain -3 -methoxy R - methyl 5 -2 - R -phenyl benzofuran -3 - N formamide. After demethyl reaction 5 - hydroxyl -2 - methyl - N-R -phenyl benzofuran -3 - formamide was obtained, and finally, formaldehyde was added. Of the cycloheximide Mannich resulted in the final product.
