1966107-70-9Relevant articles and documents
Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex
Calabrese, David R.,Hewitt, William M.,Alden, Stephanie,Hilimire, Thomas A.,Saunders, Lindsey B.,Schneekloth, John S.,Chen, Xiang,He, Fahu,Walters, Kylie J.,Leon, Elena C.,Gaikwad, Snehal M.,Phyo, Zaw,Michalowski, Aleksandra M.,Simmons, John K.,Zhang, Shuling,Connors, Daniel,Mock, Beverly A.
, (2018)
G-quadruplexes (G4s) are noncanonical DNA structures that frequently occur in the promoter regions of oncogenes, such as MYC, and regulate gene expression. Although G4s are attractive therapeutic targets, ligands capable of discriminating between differen
