72873-27-9

Basic information

• Product Name: (5-acetyl-2-ethoxycarbonyl-1H-indol-3-yl)methyl-dimethylazanium chloride
• Synonyms: L-Ala cyclohexyl ester;L-alanine cyclohexyl ester;(S)-2-Amino-propionic acid cyclohexyl ester
• CAS NO: 72873-27-9
• Molecular Formula: C9H17NO2
• Molecular Weight: 171.239
• Mol File: 72873-27-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (5-acetyl-2-ethoxycarbonyl-1H-indol-3-yl)methyl-dimethylazanium chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (5-acetyl-2-ethoxycarbonyl-1H-indol-3-yl)methyl-dimethylazanium chloride(72873-27-9)
• EPA Substance Registry System: (5-acetyl-2-ethoxycarbonyl-1H-indol-3-yl)methyl-dimethylazanium chloride(72873-27-9)

Safety Data

• Hazardous Substances Data: 72873-27-9(Hazardous Substances Data)

Usage

General Description

The chemical (5-acetyl-2-ethoxycarbonyl-1H-indol-3-yl)methyl-dimethylazanium chloride, also known as 5-Acetyltryptamine chloride, is a synthetic organic compound with the molecular formula C18H23ClN2O3. It is a derivative of tryptamine and is commonly used in scientific research as a precursor for the synthesis of various serotonin receptor ligands. The compound has a 5-acetyl moiety, an ethoxycarbonyl group, and a methyl-dimethylazanium chloride, and is typically used in pharmacological studies related to serotonin receptors and related biological systems. It is important to handle this chemical with care and follow proper safety protocols when working with it in laboratory settings.

Upstream product

• 4132-86-9 N-benzyloxycarbonylalanine 
• 108-93-0 cyclohexanol 
• 56-41-7 L-alanin 

Downstream Products

• 108260-12-4 DL-acetylamino alanine cyclohexyl ester 
• 108260-12-4 L-N-acetyl alanine cyclohexyl ester 
• 1353757-59-1 (S)-cyclohexyl 2-(dibenzylamino)propanoate 
• 1353757-82-0 C₁₆H₂₃NO₂ 
• 1353757-57-9 (S)-cyclohexyl 2-[benzyl(methyl)amino]propanoate 
• 1353757-58-0 (S)-cyclohexyl 2-[allyl(benzyl)amino]propanoate 
• 1353757-79-5 (S,E)-cyclohexyl 2-[allyl(2-tosylpenta-1,4-dienyl)amino]propanoate 
• 1353757-60-4 (S)-cyclohexyl 2-(diallylamino)propanoate 
• 1615696-43-9 C₁₅H₁₉Cl₂FNO₄P 
• 1615696-46-2 (2S)-cyclohexyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-ethoxy-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate 
• 1615696-55-3 (2S)-cyclohexyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate 
• 220592-67-6 O-phenyl-N-(S)-1-(cyclohexoxycarbonyl)ethylphosphoramidic chloride 
• 1353757-62-6 (S)-cyclohexyl 2-(piperidin-1-yl)propanoate 
• 1353757-61-5 (S)-cyclohexyl 2-(dimethylamino)propanoate 

Relevant articles and documents

Progress toward an amplifiable metabolic label for DNA: Conversion of 4-thiothymidine (4sT) to 5-methyl-2′-deoxycytidine and synthesis of a 4sT phosphorodiamidate prodrug

The ability to metabolically label DNA in a way that produces a latent change from one nucleobase to another would create a signal that can be amplified by PCR-this in turn would allow studies of newly synthesized DNA using high-throughput sequencing. To function as an amplifiable metabolic label, a nucleotide analogue would need to be taken up by cells and incorporated into cellular DNA; after purification of DNA, it could be converted into a different nucleobase with a different base pairing pattern. We selected 4-thiothymidine (4sT) as a candidate metabolic label: 4sT is readily taken up by a large number of polymerases in vitro, and we present a method that allows 4sT to be converted into 5-methyl-2′-deoxycytidine (5mC) after incorporation into DNA. Encouraged by these results, we treated cells with 4sT nucleoside; however, we found that 4sT is not incorporated into DNA in bacterial, yeast, or mammalian cells to useful levels under the conditions we tested. A phosphorodiamidate prodrug of 4sTMP was successfully synthesized but did not measurably improve incorporation into cellular DNA.

BASE-MODIFIED CYTIDINE NUCLEOTIDES FOR LEUKEMIA THERAPY

Compounds of the formula I wherein X is a bond or -CH2, and pharmaceutically acceptable salts thereof are useful in the parenteral treatment of leukemia, myelodysplastic syndrome or lymphoma, especially in patients presenting with cytarabine re

ENANTIOSELECTIVE HYDROLYSIS BY BAKER'S YEAST - II. ESTERS OF N-ACETYL AMINO ACIDS

D-N-Acetyl amino acid esters were obtained via enantioselective hydrolysis of their racemates by use of fermenting yeast.Evidence is given that proteinases are the enzymes involved.