72881-75-5Relevant academic research and scientific papers
From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity
Abdel-Halim, Mohammad,Sigler, Sara,Racheed, Nora A. S.,Hefnawy, Amr,Fathalla, Reem K.,Hammam, Mennatallah A.,Maher, Ahmed,Maxuitenko, Yulia,Keeton, Adam B.,Hartmann, Rolf W.,Engel, Matthias,Piazza, Gary A.,Abadi, Ashraf H.
supporting information, p. 4462 - 4477 (2021/05/04)
A ligand-based approach involving systematic modifications of a trisubstituted pyrazoline scaffold derived from the COX2 inhibitor, celecoxib, was used to develop novel PDE5 inhibitors. Novel pyrazolines were identified with potent PDE5 inhibitory activit
COMPOUNDS AND COMPOSITIONS FOR NEMATODE TREATMENT
-
Paragraph 0174; 0175, (2021/10/02)
Disclosed herein are compounds and compositions for nematode treatment. In particular, disclosed are compounds of formula (I), a method of treating a plant or a growing media for a nematode with compounds of formula (II), compositions, and methods of use.
Asymmetric transfer hydrogenation of cycloalkyl vinyl ketones to allylic alcohols catalyzed by ruthenium amido complexes
Liu, Sensheng,Cui, Peng,Wang, Juan,Zhou, Haifeng,Liu, Qixing,Lv, Jinliang
supporting information, p. 264 - 267 (2019/01/10)
A chemoselective 1,2-reduction of cycloalkyl vinyl ketones via asymmetric transfer hydrogenation is described. The reduction proceeded smoothly with a chiral diamine ruthenium complex as a catalyst and a HCOOH-NEt3 azeotrope as both a hydrogen source and solvent under mild conditions. A wide range of 1-cycloalkyl chiral allylic alcohols were obtained in good yields and up to 87% ee. It was found that the alkyl group plays an important role in the enantioselectivity.
Synthesis and biological evaluation of novel pyrazoline derivatives as anti-inflammatory and antioxidant agents
Khalil, Nadia A.,Ahmed, Eman M.,El-Nassan, Hala B.,Ahmed, Osama K.,Al-Abd, Ahmed M.
body text, p. 995 - 1002 (2012/10/08)
A series of novel 5-aryl-3-cyclopropyl-4,5-dihydropyrazole derivatives 2a-p were synthesized via cyclization of chalcones 1a-h with thiosemicarbazide or semicarbazide HCl and evaluated as anti-inflammatory/antioxidant agents. The structures were confirmed
Synthesis and antimicrobial evaluation of some heterocyclic chalcone derivatives
Hamada, Nagwa Mohamed Mahrous,Sharshira, Essam Mohamed
experimental part, p. 2304 - 2312 (2011/05/07)
Some new heterocyclic compounds containing isoxazole, pyrazole and oxadiazole ring systems were prepared from various chalcones. The synthesized compounds have been characterized by elemental analysis and spectral methods. These compounds were screened fo
Synthesis and in vitro antimicrobial activity of some pyrazolyl-1- carboxamide derivatives
Sharshira, Essam Mohamed,Mahrous Hamada, Nagwa Mohamed
experimental part, p. 7736 - 7745 (2011/11/04)
A series of 3,5-disubstituted pyrazole-1-carboxamides were obtained by treatment of chalcones with semicarbazide hydrochloride in dioxane containing sodium acetate/acetic acid as a buffer solution. N-acetyl derivatives of pyrazole-1-carboxamides were isol
Tetraalkylammonium and 1,3-dialkylimidazolium salts with fluorinated anions as recoverable phase-transfer catalysts in solid base-promoted cross-aldol condensations
Kryshtal, Galina V.,Zhdankina, Galina M.,Zlotin, Sergei G.
, p. 2822 - 2827 (2007/10/03)
Tetraalkylammonium and 1,3-dialkylimidazolium tetrafluoroborates and hexafluorophosphates were employed for the first time as recoverable phase-transfer catalysts in multiphase reactions of CH-acids, in particular in solid base-pro-moted cross-aldol condensations. The catalysts retained their catalytic activity over several reaction cycles.
Dialkylaminophenylethyl (or vinyl) cyclopropyl carbinols
-
, (2008/06/13)
Aryl substituted diketones and keto-esters, useful as antiviral agents and insecticides, are prepared by reacting an arylalkyl or arylalkenyl iodide with a metal salt of the appropriate diketone or keto-ester. The intermediate iodides are prepared by cond
Aryl substituted diketones
-
, (2008/06/13)
Aryl substituted diketones and keto-esters, useful as antiviral agents and insecticides, are prepared by reacting an arylalkyl or arylalkenyl iodide with a metal salt of the appropriate diketone or keto-ester.
Methylenedioxyphenyl substituted aliphatic diketones
-
, (2008/06/13)
Aryl substituted diketones and keto-esters, useful as antiviral agents and insecticides, are prepared by reacting an arylalkyl or arylalkenyl iodide with a metal salt of the appropriate diketone or keto-ester.
