728944-77-2Relevant academic research and scientific papers
A Radical-Polar Crossover Annulation to Access Terpenoid Motifs
Thomas, William P.,Schatz, Devon J.,George, David T.,Pronin, Sergey V.
supporting information, p. 12246 - 12250 (2019/08/27)
A new catalytic radical-polar crossover annulation between two unsaturated carbonyl compounds is described. The annulation proceeds under exceptionally mild conditions and provides direct and expedient access to complex terpenoid motifs. Application of this chemistry allows for synthesis of forskolin, a densely functionalized terpenoid, in 14 steps from commercially available material.
Radical cyclization of epoxynitriles mediated by titanocene chloride
Fernández-Mateos,Burón, L. Mateos,Clemente, R. Rabanedo,Ramos Silvo, Ana I.,González, R. Rubio
, p. 1011 - 1014 (2007/10/03)
The reductive radical cyclization of β-, γ-, δ- and ε-epoxynitriles has been achieved using titanocene chloride. The reaction was regioselective and afforded cyclic β-hydroxyketones in good yield. The catalytic version of this radical cyclization is also
Synthesis of a CDE fragment of the insect antifeedant 12-hydroxyazadiradione
Fernandez-Mateos, Alfonso,Coca, Gustavo Pascual,Gonzalez, Rosa Rubio,Hernandez, Carolina Tapia
, p. 9097 - 9102 (2007/10/03)
A diastereoselective and versatile synthesis of the model insect antifeedant 23 related to 12-hydroxyazadiradione has been achieved in 11 steps starting from α-cyclocitral, 1. The key steps involve intramolecular 1,3-dipolar cycloaddition of a nitrile oxide and a Stille coupling reaction of a vinyl iodide with a stannylfuran.
