728944-93-2

Upstream product

• 281190-97-4 (2R,3E,1'S,1''R,2''S)-1''-[(p-tolylsulfonyl)amino]indan-2''-yl 2-[3'-(benzyloxy)-1'-hydroxypropyl]-4-phenylbut-3-enoate 
• 281191-01-3 (2R,2'E,5'S,6'R,7'E)-tert-butyl 3-(4-methoxyphenyl)-2-({6'-methyl-8'-phenyl-5'-[(triisopropylsilanyl)oxy]octa-2',7'-dienoyl}amino)propionate 
• 281190-96-3 (3E,1'R,2'S)-1'-[(p-tolylsulfonyl)amino]indan-2-yl 4-phenylbut-3-enoate 
• 281190-99-6 (1S,2R,3E)-({1-[2'-(benzyloxy)ethyl]-2-methyl-4-phenylbut-3-enyl}oxy)triisopropylsilane 
• 281191-00-2 (2E,5S,6R,7E)-ethyl 6-methyl-8-phenyl-5-[(triisopropylsilanyl)oxy]octa-2,7-dienoate 
• 281190-94-1 (2E,5S,6R,7E)-6-methyl-8-phenyl-5-[(triisopropylsilanyl)oxy]octa-2,7-dienoic acid 
• 728944-91-0 (R)-tert-butyl 2-{[(benzyloxy)carbonyl]amino}-3-(4-methoxyphenyl)propionate 
• 281191-04-6 (3S,4R,5E)-4-methyl-6-phenyl-3-[(triisopropylsilanyl)oxy]hex-5-en-1-ol 
• 728944-90-9 (2S,3S)-5-(benzyloxy)-2-[(E)-styryl]pentane-1,3-diol 
• 281191-05-7 (3S,4R,5E)-4-methyl-6-phenyl-3-[(triisopropylsilanyl)oxy]hex-5-enal 
• 281190-98-5 (3S,4R,5E)-1-(benzyloxy)-4-methyl-6-phenylhex-5-en-3-ol 
• 281190-95-2 (R)-tert-butyl 2-amino-3-(4-methoxyphenyl)propionate 
• 219606-82-3 (2S,2'R)-benzyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}propionyl)oxy]-4-methylpentanoate 
• 65806-89-5 (R)-2-{[(benzyloxy)carbonyl]amino}-3-(4-methoxyphenyl)propionic acid 

Downstream Products

• 162600-54-6 cryptophycin-24 
• 162473-78-1 desepoxyarenastatin A 

Relevant academic research and scientific papers

Asymmetric syntheses of potent antitumor macrolides cryptophycin B and arenastatin A

Efficient and highly stereoselective syntheses of cryptophycin B and arenastatin A, potent cytotoxic agents, are described. An ester-derived titanium enolate mediated syn-aldol reaction was employed to generate the stereocenters C-5 and C-6. The route is convergent and provides a convenient access to the synthesis of structural variants of cryptophycins as well as members of its family. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004).