72913-08-7

Upstream product

• 3483-19-0 3-(4-methylphenyl)sydnone 
• 64-19-7 acetic acid 
• 134863-50-6 3-3-(4-tolyl)-4-(1-hydroxyethyl)sydnone 
• 108-24-7 acetic anhydride 

Downstream Products

• 84877-59-8 3-p-tolylsydnone-4-N-methylcarboxamide 
• 76242-34-7 4-bromoacetyl-3-(4-methylphenyl)sydnone 
• 134863-50-6 3-3-(4-tolyl)-4-(1-hydroxyethyl)sydnone 
• 7625-02-7 5-methyl-2-phenyl-4-(2-phenylhydrazono)-2,4-dihydro-3H-pyrazol-3-one 
• 352025-97-9 C₁₉H₁₅N₃O₅ 
• 213249-77-5 C₁₈H₁₄N₂O₃ 
• 946612-42-6 C₁₈H₁₃Br₃N₂O₃ 
• 489474-59-1 C₁₈H₁₄Br₂N₂O₃ 

Relevant academic research and scientific papers

Acylation of sydnones with acetic anhydride in the presence of Montmorillonite K-10

Various-4-acetyl sydnones 2 can be prepared in good yield by reaction of the corresponding 3-arylsydnones (cf. 1) with acetic anhydride at ~ 110°C catalyzed by Montmorillonite K-10. The reaction fails where an ortho-keto moiety is present; therein sydnone

Pyridine-catalyzed synthesis of quinoxalines as anticancer and anti-tubercular agents

Quinoxaline derivatized with coumarin viz., 3a–f and with sydnones viz., 7a–0 were synthesized using pyridine as catalyst. Among the coumarin derivatives, 3a and 3b have been screened for anticancer activity against 60 human cancer cell lines at NIH (USA)

Bismuth triflate-catalyzed friedel-crafts acylations of sydnones

Friedel-Crafts acylations of various 3-arylsydnones at the C4 position have been achieved in good yields using 4 equivalents of an alkyl anhydride and 25mol% each of bismuth triflate and lithium perchlorate in anhydrous acetonitrile at 95C. Acylations app

Synthesis, antibacterial and analgesic activities of 4-[1-oxo-3-(substituted aryl)-2-propenyl]-3-(4-methylphenyl) sydnones

A series of sydnone derivatives containing styryl ketone moiety, 4-[1-oxo-3-(substituted aryl)-2-propenyl]-3-(4-methylphenyl)sydnones (6a-i) has been synthesized and characterized by spectral data. The synthesized compounds have been screened for prelimin

N-Bromosuccinimide (NBS) as Promoter for Acylation of Sydnones in the Presence of Acetic Anhydride under Neutral Conditions

Various 4 - acetyl sydnones (2) can be prepared by reaction of the corresponding 3-aryl sydnones (1) with acetic anhydride at ~110 °C promoted by N-Bromosuccinimide (NBS) as an effective reagent for acylation of sydnones under neutral conditions in satisf

1,3-Dibromo-5,5-dimethylhydantoin (DBH) as an efficient promoter for acetylation of 3-arylsydnones in the presence of acetic anhydride under neutral conditions

(Chemical Equation Presented) 1,3-Dibromo-5,5-dimethylhydantoin (DBH) has been found to efficiently promote the conversion of various 3-arylsydnones to their 4-acetyl congeners in the presence of acetic anhydride under neutral conditions in satisfactory y

Synthesis and biological study of some novel 4-[5-(4,6-disubstituted-2- thiomethylpyrimidyl)-4'-amino-1,2,4- triazol-3'-yl] thioacetyl-3-arylsydnones

A series of 4-[5-(4,6-disubstituted-2-thiomethyl pyrimidyl)-4'-amino-1,2-4- triazol-3'-yl]thioacetyl-3-arylsydnones 7a-i were synthesized by the reaction of 5-(4,6-disubstituted-2-thiomethylpyrimidyl)-4-amino-3-mercapto-1,2-4-triazoles 3 with 3-aryl-4-bromoacetyl sydnones 6 in an ethanol medium. The newly synthesized compounds 7a-i were screened for their antibacterial activity against E. coli and Serratia marcesens and for antibacterial activity against Aspergillus niger and Pencillium. Most of the tested compounds showed significant antifungal activity particularly against Pencillium at 10-g/mL concentration comparable with that of the standard drug Flukanazole.

Oxidation of 3-Aryl-4-(1-Hydroxyethyl)sydnones Using DMSO-Ac2O as Oxidant

Treatment of 3-aryl-4-(1-hydroxyethyl)sydnones with DMSO-Ac2O yielded esters and ketones, depending on the amount of Ac2O used; application of a limited amount of Ac2O with DMSO as an oxidant has been found to be the only method to convert the title compounds to the ketones.