7292-71-9

Basic information

• Product Name: AMINO-(3-CHLORO-PHENYL)-ACETIC ACID
• Synonyms: 2-aMino-2-(3-chlorophenyl)acetic acid;2-(3-Chlorophenyl)glycine;DL-2-(3-Chlorophenyl)glycine;alpha-Amino-3-chlorophenylacetic acid;Benzeneacetic acid, alpha-amino-3-chloro-;(S)-AMINO-(3-CHLORO-PHENYL)-ACETIC ACID;RARECHEM AK ML 0507;DL-(3-CHLOROPHENYL)GLYCINE
• CAS NO: 7292-71-9
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.61
• Product Categories: Pharmaceutical Raw Materials;pharmacetical
• Mol File: 7292-71-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 268-269℃ (decomposition)
• Boiling Point: 316.9 °C at 760 mmHg
• Flash Point: 145.4 °C
• Appearance: /
• Density: 1.392 g/cm³
• Vapor Pressure: 0.000168mmHg at 25°C
• Refractive Index: 1.603
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Aqueous Acid (Slightly), Methanol (Very Slightly, Heated)
• PKA: 1.76±0.10(Predicted)
• CAS DataBase Reference: AMINO-(3-CHLORO-PHENYL)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: AMINO-(3-CHLORO-PHENYL)-ACETIC ACID(7292-71-9)
• EPA Substance Registry System: AMINO-(3-CHLORO-PHENYL)-ACETIC ACID(7292-71-9)

Safety Data

• Hazardous Substances Data: 7292-71-9(Hazardous Substances Data)

Usage

Uses

Amino(3-?chlorophenyl)?acetic Acid functions as intermediate useful in the preparation of synthetic penicillins, also used in the structure-activity relationship examination of several drugs containing the benzyl moiety, their roles in biochemical and pharmacological processes.

InChI:InChI=1/C8H8ClNO2/c9-6-3-1-2-5(4-6)7(10)8(11)12/h1-4,7H,10H2,(H,11,12)

Upstream product

• 71737-94-5 5-(m-chlorophenyl)hydantoin 
• 25698-37-7 D‐3‐chlorophenylglycine 
• 16273-37-3 3-chloromandelic acid 
• 587-04-2 m-Chlorobenzaldehyde 
• 532987-11-4 methyl 2-(3-chlorophenyl)glycinate 
• 26767-07-7 2-(3-chlorophenyl)-2-oxoacetic acid 
• 97070-75-2 2-(3-chlorophenyl)-2-hydroxyacetonitrile 
• 891790-02-6 C₁₆H₁₅ClN₂O 
• 93554-79-1 alpha-amino-(3-chlorophenyl)acetonitrile 

Downstream Products

• 1474012-48-0 C₁₀H₅ClF₃NO₂ 
• 1019321-43-7 2-(3-chlorophenyl)aziridine 
• 25698-37-7 D‐3‐chlorophenylglycine 
• 119565-00-3 L‐3‐chlorophenylglycine 
• 3381-74-6 α-Bromo-(3-chlorophenyl)acetic acid 

Relevant articles and documents

Synthesis of Unprotected 2-Arylglycines by Transamination of Arylglyoxylic Acids with 2-(2-Chlorophenyl)glycine

The transamination of α-keto acids with 2-phenylglycine is an effective methodology for directly synthesizing unprotected α-amino acids. However, the synthesis of 2-arylglycines by transamination is problematic because the corresponding products, 2-arylglycines, transaminate the starting arylglyoxylic acids. Herein, we demonstrate the use of commercially available l-2-(2-chlorophenyl)glycine as the nitrogen source in the transamination of arylglyoxylic acids, producing the corresponding 2-arylglycines without interference from the undesired self-transamination process.

PLATELET ADP RECEPTOR INHIBITORS

Compounds are provided which are useful as platelet ADP receptor inhibitors, for treating thrombosis and for reducing the likelihood and/or severity of a secondary ischemic event in a patient.

Synthesis of some chlorosubstituted DL-phenylamino acid alkylester hydrochlorides

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