119565-00-3

Basic information

• Product Name: L-3-CHLOROPHENYLGLYCINE
• Synonyms: L-3-CHLOROPHENYLGLYCINE;(S)-2-(3-Chlorophenyl)glycine;Benzeneacetic acid,α-aMino-3-chloro-,(S)-;(S)-alpha-Amino-3-chlorobenzeneacetic acid;(S)-2-Amino-2-(3-chlorophenyl)acetic acid;(2S)-2-Amino-2-(3-chlorophenyl)acetic acid
• CAS NO: 119565-00-3
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.61
• Mol File: 119565-00-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 232℃
• Boiling Point: 316.9±32.0 °C(Predicted)
• Appearance: /
• Density: 1.392±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.76±0.10(Predicted)
• CAS DataBase Reference: L-3-CHLOROPHENYLGLYCINE(CAS DataBase Reference)
• NIST Chemistry Reference: L-3-CHLOROPHENYLGLYCINE(119565-00-3)
• EPA Substance Registry System: L-3-CHLOROPHENYLGLYCINE(119565-00-3)

Safety Data

• Hazardous Substances Data: 119565-00-3(Hazardous Substances Data)

Usage

General Description

L-3-chlorophenylglycine is a chemical compound with the molecular formula C8H8ClNO2. It is an amino acid derivative with a chlorine atom attached to the phenyl ring. L-3-chlorophenylglycine is used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also a useful intermediate in chemical research and can be utilized in the development of new drugs and materials. L-3-chlorophenylglycine may also have potential applications in the production of specialty chemicals and fine chemicals due to its unique chemical properties and reactivity.

Upstream product

• 93554-79-1 alpha-amino-(3-chlorophenyl)acetonitrile 
• 587-04-2 m-Chlorobenzaldehyde 
• 7292-71-9 2-(3-chlorophenyl)glycine 
• 67-66-3 chloroform 

Relevant articles and documents

Investigation of Taniaphos as a chiral selector in chiral extraction of amino acid enantiomers

Finding chiral selector with high stereoselectivity to a variety of amino acid enantiomers remains a challenge and warrants further research. In this work, Taniaphos, a chiral ligand with rotatable spatial configuration, was employed as a chiral extractant to enantioseparate various amino acid enantiomers. Phenylalanine (Phe), homophenylalanine (Hphe), 4-nitrophenylalanine (Nphe), and 3-chloro-phenylglycine (Cpheg) were used as substrates to evaluate the extraction efficiency. The results revealed that Taniaphos-Cu exhibited good abilities to enantioseparate Phe, Hphe, Nphe, and Cpheg with the highest separation factors (α) of 3.13, 2.10, 2.32, and 2.14, respectively. Taniaphos-Cu is more conducive to combine with D-amino acid in extraction. The influences of pH, Taniaphos-Cu, and concentration and extraction temperature on extraction were comprehensively evaluated. The highest performance factors (pf) for Phe, Hphe, Nphe, and Cpheg at optimal extraction conditions were 0.08892, 0.1250, 0.09621, and 0.08021, respectively. The recognition mechanism between Taniaphos-Cu and amino acid enantiomers was discussed. The coordination interaction between Taniaphos-Cu and -COO?, π-π interaction between Taniaphos-Cu and amino acid enantiomers are important acting forces in chiral extraction. The steric-hindrance between -NH2 and -OH lead to Taniaphos-Cu-D-Phe is more stable than Taniaphos-Cu-L-Phe. This work provided a chiral extractant that has good abilities to enantioseparate various amino acid enantiomers.

Method for splitting 3-chlorine-phenylglycine enantiomers

The invention relates to the technical field of medicinal chemistry, in particular to a method for splitting 3-chlorine-phenylglycine enantiomers. The method for splitting the 3-chlorine-phenylglycineenantiomers comprises the steps that a diphosphine liga

Highly efficient and enantioselective synthesis of L-arylglycines and D-arylglycine amides from biotransformations of nitriles

Under very mild conditions, the Rhodococcus sp. AJ270-catalysed biotransformation of arylglycine nitriles 1, prepared easily from the reaction of substituted benzaldehydes, ammonium chloride and potassium cyanide, proceeded efficiently to produce optically active D-arylglycine amides 2 and L-arylglycines 3 in excellent yields with enantiomeric excesses higher than 99%.