Synthesis of the optically pure monoethyl ester of (R)-(+)-2-fluoromalonic acid by use of immobilized lipase-my for asymmetric hydrolysis

Article abstract of DOI:10.1016/S0022-1139(00)80530-8

A synthetic approach to optically pure (+)-2-fluoromalonic acid monoethyl ester was based on the enantiotopic specificity of asymmetric hydrolysis by an immobilized enzyme. The absolute configuration of monoethyl (+)-2-fluoromalonate was determined : it is the (R)-enantiomer.