729612-85-5

Upstream product

• 103360-04-9 4-fluorobenzylsulfonyl chloride 
• 179524-34-6 t-Butyl (3-Amino-6-methyl-2-oxo-1,2-dihydro-1-pyridyl)acetate 

Downstream Products

• 729612-88-8 2-[3-{[(4-fluorobenzyl)sulfonyl]amino}-6-methyl-2-oxo-1(2H)-pyridinyl]acetic acid 

Relevant academic research and scientific papers

Novel pyrazinone and pyridinone thrombin inhibitors incorporating weakly basic heterobicyclic P1-arginine mimetics

The design, synthesis and biological activity of new thrombin inhibitors with a pyridinone or pyrazinone core and different heterobicyclic P1 arginine side-chain mimetics are described. The arginine side-chain mimetics used in this study are (±

Novel thrombin inhibitors incorporating weakly basic heterobicyclic P1-arginine mimetics: optimization via modification of P1 and P3 moieties.

Optimization of lead compounds 1 and 2 resulted in novel, selective, and potent thrombin inhibitors incorporating weakly basic heterobicyclic P(1)-arginine mimetics. The design, synthesis, and biological activity of racemic thrombin inhibitors 17-29 and enantiomerically pure thrombin inhibitors 30-33 are described. The arginine side-chain mimetics used in this study are 4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine, 4,5,6,7-tetrahydro-2H-indazole, and 2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3(2H)-ylamine.