730-70-1

Basic information

• Product Name: 1H-Isoindol-1-one, 3-(4-chlorophenyl)-2,3-dihydro-3-hydroxy-2-methyl-
• CAS NO: 730-70-1
• Molecular Weight: 273.719
• Mol File: 730-70-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Isoindol-1-one, 3-(4-chlorophenyl)-2,3-dihydro-3-hydroxy-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindol-1-one, 3-(4-chlorophenyl)-2,3-dihydro-3-hydroxy-2-methyl-(730-70-1)
• EPA Substance Registry System: 1H-Isoindol-1-one, 3-(4-chlorophenyl)-2,3-dihydro-3-hydroxy-2-methyl-(730-70-1)

Safety Data

• Hazardous Substances Data: 730-70-1(Hazardous Substances Data)

Upstream product

• 59325-17-6 ethyl benzyl(methyl)carbamate 
• 103-67-3 benzyl-methyl-amine 
• 85-56-3 2-(4-chlorobenzoyl)benzoic acid 
• 55275-44-0 4'-chloro-o-benzoylbenzoic acid chloride 
• 74-89-5 methylamine 

Relevant articles and documents

Tandem C(sp3)?H Arylation/Oxidation and Arylation/Allylic Substitution of Isoindolinones

Isoindolinones comprise an important class of medicinally active compounds. Herein we report a straightforward functionalization of isoindolinones with aryl bromides (22 examples) using a palladium(II) acetate/NIXANTPHOS-based catalyst system. Additionally 3-aryl-3-hydroxyisoindolinone derivatives, which exhibit anti-tumor activity, can be accessed via a tandem reaction. Thus, when the arylation product is exposed to air under basic conditions, in situ oxidation takes place to install the 3-hydroxy group. Furthermore, a tandem arylation/allylic substitution reaction is advanced in which both the arylation and allylic substitution are catalyzed by the same palladium catalyst. Finally, a tandem arylation/alkylation procedure is presented. These tandem reactions enable the synthesis of a variety of structurally diverse isoindolinone derivatives from common starting materials. (Figure presented.).