7301-86-2

Basic information

• Product Name: Phosphoric acid, cyclohexyl diethyl ester
• CAS NO: 7301-86-2
• Molecular Formula: C10H21O4P
• Molecular Weight: 236.248
• Mol File: 7301-86-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Phosphoric acid, cyclohexyl diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphoric acid, cyclohexyl diethyl ester(7301-86-2)
• EPA Substance Registry System: Phosphoric acid, cyclohexyl diethyl ester(7301-86-2)

Safety Data

• Hazardous Substances Data: 7301-86-2(Hazardous Substances Data)

Upstream product

• 22096-22-6 sodium cyclohexanolate 
• 814-49-3 diethyl chlorophosphate 
• 108-93-0 cyclohexanol 
• 2404-03-7 diethyl N,N-dimethylphosphoramide 
• 17448-45-2 phosphorous acid diethyl ester-cyclohexyl ester 
• 110-82-7 cyclohexane 
• 122-52-1 triethyl phosphite 
• 681035-21-2 (2-oxo-5,5-diphenyl-oxazolidin-3-yl)-phosphonic acid diethyl ester 
• 108678-42-8 Cyclohexyloxy-diethyl-borane 
• 78-40-0 triethyl phosphate 

Downstream Products

• 2870-30-6 sodium diethyl phosphate 
• 108-93-0 cyclohexanol 

Relevant articles and documents

Identification of organophosphorus simulants for the development of next-generation detection technologies

Organophosphorus (OP) chemical warfare agents (CWAs) represent an ongoing threat but the understandable widespread prohibition of their use places limitations on the development of technologies to counter the effects of any OP CWA release. Herein, we describe new, accessible methods for the identification of appropriate molecular simulants to mimic the hydrogen bond accepting capacity of the PO moiety, common to every member of this class of CWAs. Using the predictive methodologies developed herein, we have identified OP CWA hydrogen bond acceptor simulants for soman and sarin. It is hoped that the effective use of these physical property specific simulants will aid future countermeasure developments.

Phosphorylation of alcohols with N-phosphoryl oxazolidinones employing copper(II) triflate catalysis

(Chemical Equation Presented) Phosphoryl transfer from N-phosphoryl 5,5-diphenyl oxazolidinone is efficiently catalyzed by copper(II) triflate. The utility of this method has been demonstrated in the phosphorylation of representative primary, secondary, tertiary, phenolic, and allylic alcohols. These reaction conditions are significantly milder than employing alkoxides and allow the phosphorylation of biologically relevant molecules.

An improved method for Lewis acid catalyzed phosphoryl transfer with Ti(t-BuO)4

Several inorganic esters have been evaluated as phosphoryl transfer catalysts. Of these, Ti(t-BuO)4 was found to be the most effective catalyst giving excellent yields of the desired phosphate esters. The loading of the catalyst could be reduced to a little as 5 mol % for a majority of substrates with no loss in the yield of product. This methodology is significantly more versatile than using TiCl4 and is suitable for the phosphorylation of more complex carbohydrates and molecules of biological interest.