73013-69-1

Usage

Uses

Used in Pharmaceutical Industry:
2-METHYL-6-QUINOLINECARBONITRILE is used as a key intermediate for the synthesis of various drugs and pharmaceutical products due to its ability to act as a building block in organic synthesis.
Used in Organic Synthesis:
2-METHYL-6-QUINOLINECARBONITRILE is used as a versatile reagent in the preparation of a range of organic compounds, contributing to the development of new chemical entities.
Used in Agrochemical Production:
2-METHYL-6-QUINOLINECARBONITRILE is utilized as a valuable starting material in the production of agrochemicals, playing a significant role in the development of agricultural products.

InChI:InChI=1/C11H8N2/c1-8-2-4-10-6-9(7-12)3-5-11(10)13-8/h2-6H,1H3

Upstream product

• 877-42-9 6-Bromo-2-methyl-quinoline 
• 544-92-3 copper(I) cyanide 
• 557-21-1 zinc(II) cyanide 

Downstream Products

• 1256347-72-4 2-(2-methyl-benzyl)-quinoline-6-carbonitrile 

Relevant academic research and scientific papers

Mild palladium-catalyzed cyanation of (hetero)aryl halides and triflates in aqueous media

A mild, efficient, and low-temperature palladium-catalyzed cyanation of (hetero)aryl halides and triflates is reported. Previous palladium-catalyzed cyanations of (hetero)aryl halides have required higher temperatures to achieve good catalytic activity. This current reaction allows the cyanation of a general scope of (hetero)aryl halides and triflates at 2-5 mol % catalyst loadings with temperatures ranging from rt to 40 °C. This mild method was applied to the synthesis of lersivirine, a reverse transcriptase inhibitor.

Synthesis of novel quinaldine-based squaraine dyes: Effect of substituents and role of electronic factors

(Chemical Equation Presented) Condensation of squaric acid with quinaldinium salts containing electron-donating substituents gave only the semisquaraines. However, with salts possessing electronegative and electron-withdrawing groups, the squaraine dyes were isolated in quantitative yields. The semisquaraines formed undergo condensation with highly nucleophilic salts yielding the unsymmetrical squaraine dyes. These results demonstrate the role of electronic factors and provide valuable information for the design of efficient squaraine-based sensitizers that can have potential applications in photodynamic therapy.