73014-19-4

Basic information

• Product Name: 1-(2,4-DIHYDROXYPHENYL)-2-PHENOXYETHAN-1-ONE
• Synonyms: 1-(2,4-DIHYDROXYPHENYL)-2-PHENOXYETHAN-1-ONE
• CAS NO: 73014-19-4
• Molecular Formula: C₁₄H₁₂O₄
• Molecular Weight: 244.24
• Mol File: 73014-19-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 207 °C
• Boiling Point: 472.6°Cat760mmHg
• Flash Point: 184°C
• Appearance: /
• Density: 1.311g/cm³
• Vapor Pressure: 1.49E-09mmHg at 25°C
• Refractive Index: 1.63
• CAS DataBase Reference: 1-(2,4-DIHYDROXYPHENYL)-2-PHENOXYETHAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4-DIHYDROXYPHENYL)-2-PHENOXYETHAN-1-ONE(73014-19-4)
• EPA Substance Registry System: 1-(2,4-DIHYDROXYPHENYL)-2-PHENOXYETHAN-1-ONE(73014-19-4)

Safety Data

• Hazardous Substances Data: 73014-19-4(Hazardous Substances Data)

Usage

Preparation

Obtained by reaction of phenoxyacetonitrile with resorcinol (Hoesch reaction).

InChI:InChI=1/C14H12O4/c15-10-6-7-12(13(16)8-10)14(17)9-18-11-4-2-1-3-5-11/h1-8,15-16H,9H2

Upstream product

• 3598-14-9 phenoxyacetonitrile 
• 108-46-3 recorcinol 
• 108-95-2 phenol 
• 25774-60-1 2-Phenoxyethansaeure-phenylester 

Downstream Products

• 137460-58-3 7-Hexyloxy-3-phenoxy-chromen-4-one 
• 137460-57-2 7-Pentyloxy-3-phenoxy-chromen-4-one 
• 137460-56-1 7-Butoxy-3-phenoxy-chromen-4-one 
• 73023-14-0 7-Methoxy-3-phenoxy-chromen-4-one 
• 87891-62-1 2-methyl-3-phenoxy-7-hydroxychromone 
• 137988-07-9 3-phenoxy-7-acetoxychromone 
• 87891-60-9 3-phenoxy-7-hydroxychromone 
• 137460-59-4 2-trifluoromethyl-3-phenoxy-7-hydroxychromone 
• 137460-60-7 2-methyl-3-phenoxy-7-acetoxychromone 

Relevant articles and documents

Rational Engineered C-Acyltransferase Transforms Sterically Demanding Acyl Donors

The biocatalytic Friedel-Crafts acylation has been identified recently for the acetylation of resorcinol using activated acetic acid esters for the synthesis of acetophenone derivatives catalyzed by an acyltransferase. Because the wild-type enzyme is limited to acetic and propionic derivatives as the substrate, variants were designed to extend the substrate scope of this enzyme. By rational protein engineering, the key residue in the active site was identified which can be replaced to allow binding of bulkier acyl moieties. The single-point variant F148V enabled the transformation of previously inaccessible medium chain length alkyl and alkoxyalkyl carboxylic esters as donor substrates with up to 99% conversion and up to >99% isolated yield.

DEVELOPMENT OF STRUCTURE - ACTIVITY TRENDS IN THE SERIES OF 3-PHENOXYCHROMONE DERIVATIVES

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