73029-29-5

Upstream product

• 6642-31-5 6-Amino-1,3-dimethylbarbituric acid 
• 43192-31-0 2-bromo-4-methoxybenzaldehyde 
• 26668-99-5 6-(3-methoxy-anilino)-1,3-dimethyl-1H-pyrimidine-2,4-dione 
• 68-12-2 N,N-dimethyl-formamide 
• 77603-09-9 1,3-dimethyl-8-methoxy-5-methylthiopyrimido<4,5-b>quinoline-2,4(1H,3H)-dione 

Relevant academic research and scientific papers

Synthesis of pyrimidine fused quinolines by ligand-free copper-catalyzed domino reactions

Herein, we report two novel methods for the synthesis of pyrimidine fused quinolines using a one-pot C-C and C-N bond forming strategy from the reaction of 6-aminouracils with 2-bromobenzaldehydes or 2-bromobenzyl bromide derivatives in the presence of 10 mol % CuCl2 without using any ligand. The reaction of 2-bromobenzaldehyde or its derivatives with 6-aminouracils in the presence of K2CO3 as base and a catalytic amount of CuCl2 in DMF medium under microwave heating conditions provides corresponding pyrimidine fused quinoline derivatives in good yields within 30 min. Alternatively, pyrimidine fused quinoline derivatives have been synthesized from the reaction of 2-bromobenzyl bromides with 6-aminouracil derivatives in the presence of molecular oxygen, CuCl2 (10 mol %), and K2CO3 as base in DMF under reflux conditions. Structures of all the products were unambiguously confirmed by spectroscopic techniques and by recording single crystal XRD of 3a.

Reaction of Enaminones with Carbon Disulfide: Synthesis of Heterocycles Using Enamino Dithiocarboxylates

Reaction of various types of enaminones, which are prepared by the condensation of 1,3-dicarbonyl compounds with aromatic amines, with carbon disulfide in the presence of sodium hydroxide as the base in dimethyl sulfoxide to give the corresponding enamino

A NEW SYNTHESIS OF PYRIMIDOQUINOLINE-2,4-(1H,3H)-DIONES BY REACTION OF 6-ARYLAMINO-1,3-DIMETHYLURACILS WITH CARBON DISULFIDE

Reaction of 6-arylaminouracils (I) with carbon disulfide in the presence of sodium hydroxide and subsequent methylation with dimethyl sulfate gave the corresponding 1,3-dimethyl-5-methylthiopyrimidoquinoline-2,4(1H,3H)-diones (II).Raney-nickel desu