73029-52-4Relevant academic research and scientific papers
Synthesis of Substituted Benzo[ b]thiophenes via Base-Promoted Domino Condensation-Intramolecular C-S Bond Formation
Kumar, Yogendra,Ila, Hiriyakkanavar
supporting information, p. 1698 - 1702 (2021/03/03)
A novel synthesis of 2,3-substituted benzothiophenes is reported, involving a tandem base-mediated condensation of o-iodoarylacetonitriles/acetates/ketones with (hetero)aryldithioesters and an intramolecular C-S bond formation. The reaction affords divers
Synthesis of N-Glycosyl-2-oxindoles by Pd-Catalyzed N-Arylation of 1-Amidosugars
Letribot, Boris,Redjdal, Wafa,Redjdal, Wafa,Benmerad, Belkacem,Le Bideau, Franck,Alami, Mouad,Messaoudi, Samir
supporting information, p. 4201 - 4206 (2020/06/04)
An efficient intramolecular Pd-catalyzed N-arylation of o-iodo-amidosugars for the synthesis of N-glycosylated oxindoles has been reported. The coupling reaction takes place in toluene and involves Pd(OAc)2/RuPhos catalytic systems in the presence of K2CO3. This versatile approach was extended successfully to the synthesis of other N-glycosylated heterocycles.
Efficient synthesis of heterocyle-fused β-naphthylamines via intramolecular addition to a cyano group initiated by nucleopalladation of alkynes
Xia, Guoqin,Han, Xiuling,Lu, Xiyan
supporting information, p. 6184 - 6187 (2015/01/09)
A palladium(II)-catalyzed efficient synthesis of heterocycle-fused-naphthylamines was accomplished via nucleophilic addition of a carbon-palladium bond to the intramolecular cyano group initiated by nucleopalladation (oxypalladation or aminopalladation) o
Methods for the treatment of hypertension
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, (2008/06/13)
Acetylene compounds of the formula (I): STR1 wherein Y, R1, R2, R3, and R4 are as described herein, m is 0-3, n is 0-2 and Ar is phenyl or an aromatic heterocycle are disclosed. The compounds possess antihyperte
Acetylene amines and their use as vasodilators and antihypertensives
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, (2008/06/13)
Acetylenes of the following formula (I): STR1 wherein Y, m, R1, R2, R3, n and R4 are defined herein and R5 is hydrogen, alkyl, cycloalkyl or substituted alkyl are useful vasodilators and antihypertens
Aralykyl (arylethynyl)aralkyl amines and their use as vasodilators and antihypertensives
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, (2008/06/13)
Acetylenes of the formula (I): STR1 wherein Y, m, R1, R2 q, Alk, R3, n and R4 are as defined herein and Ar1 and Ar2 are aromatic, including the salts and ammonium derivatives of formula (I), in treating angina, hypertension and cardiac arrhythmias. Pharmaceutical compositions, methods of use and synthesis and novel intermediates are also part of the invention.
