99540-02-0

Upstream product

• 13146-23-1 copper(I) phenylacetylenide 
• 99540-37-1 2-iodo-5-methoxy-N,N-dimethylbenzeneethanamine 
• 536-74-3 phenylacetylene 
• 99540-20-2 (6-iodo-3-methoxy)phenyl-N,N-dimethylacetamide 
• 112399-38-9 (2-Iodo-5-methoxy-phenyl)-acetyl chloride 
• 73029-52-4 2-(2-iodo-5-methoxyphenyl)acetic acid 

Relevant academic research and scientific papers

Methods for the treatment of hypertension

Acetylene compounds of the formula (I): STR1 wherein Y, R1, R2, R3, and R4 are as described herein, m is 0-3, n is 0-2 and Ar is phenyl or an aromatic heterocycle are disclosed. The compounds possess antihyperte

2-Ethynylbenzenealkanamines. A new class of calcium entry blockers

A series of 2-(aryl- or alkylethynyl)benzenealkanamines were synthesized. They exhibit antihypertensive activity in spontaneously hypertensive rats and coronary vasodilator activity with minimal negative inotropic activity in the 'Langendorff' guinea pig heart in vitro. They have been shown to exert their activity by inhibition of Ca2+ influx across cell membranes. Optimal activity is found among the N-(arylethyl)-5-methoxy-α-methyl-2-(phenylethynyl)benzeneethanamines and -propanamines.