73048-49-4

Basic information

• Product Name: Benzenemethanol, 4-nitro-alpha-(trifluoromethyl)-, (S)- (9CI)
• Synonyms: Benzenemethanol, 4-nitro-alpha-(trifluoromethyl)-, (S)- (9CI)
• CAS NO: 73048-49-4
• Molecular Formula: C8H6F3NO3
• Molecular Weight: 221.1333496
• Product Categories: ACETYLHALIDE
• Mol File: 73048-49-4.mol
• Article Data: 20

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenemethanol, 4-nitro-alpha-(trifluoromethyl)-, (S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 4-nitro-alpha-(trifluoromethyl)-, (S)- (9CI)(73048-49-4)
• EPA Substance Registry System: Benzenemethanol, 4-nitro-alpha-(trifluoromethyl)-, (S)- (9CI)(73048-49-4)

Safety Data

• Hazardous Substances Data: 73048-49-4(Hazardous Substances Data)

Upstream product

• 426-58-4 (trifluoromethylsulfonyl)benzene 
• 555-16-8 4-nitrobenzaldehdye 
• 619-73-8 4-nitrobenzyl chloride 
• 241127-76-4 2,2,2-trifluoro-1-(4-nitrophenyl)ethan-1-ol 
• 97-72-3 2-Methylpropionic anhydride 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 75-46-7 trifluoromethan 

Downstream Products

• 1135312-08-1 (R)-2,2,2-trifluoro-1-(4'-nitrophenyl)ethanol 
• 1135311-93-1 (S)-2,2,2-trifluoro-1-(4'-nitrophenyl)ethyl isobutyrate 

Relevant articles and documents

Fluorine-18 labelled Ruppert-Prakash reagent ([18F]Me3SiCF3) for the synthesis of 18F-trifluoromethylated compounds

This article describes the first synthesis and application of fluorine-18 labelled Ruppert-Prakash reagent [18F]Me3SiCF3. [18F]Me3SiCF3 was synthesized from [18F]fluoroform with radiochemical yields of 85-95% and radiochemical purities of >95% within 20 m

FLUOROALKYLATING AGENT

Problem to be Solved It is intended to provide an industrially preferable fluoroalkylating agent and use thereof. Solution The present invention provides a fluoroalkylating agent represented by the general formula (1) wherein R1 is a C1 to C8 fluoroalkyl group; R2 and R3 are each independently a C1 to C12 alkyl group or the like; Y1 to Y4 are each independently a hydrogen atom, a halogen atom, or the like; and X? is a monovalent anion. A compound of the general formula (3): R4—S—R1 having an introduced C1 to C8 fluoroalkyl group is easily obtained by reacting a compound of the general formula (2): R4—S—Z wherein R4 is a hydrocarbon group or the like; and Z is a leaving group, with the compound of the general formula (1).

A method of manufacturing a trifluoromethyl group-containing compound

PROBLEM TO BE SOLVED: To provide a method for producing a trifluoromethyl group-containing compound useful as a synthetic intermediate for a pharmaceutical or an agricultural chemical product.SOLUTION: There is provided a method for producing a trifluoromethyl group-containing compound represented by the following general formula (2) which is obtained by reacting a carbonyl compound having a specific structure with trifluoromethane and an organic base in an organic solvent (wherein, Rrepresents a methyl group, an ethyl group, a linear, branched or cyclic alkyl group having 3 to 10 carbon atoms, a phenyl group, a substituted phenyl group, a naphthyl group, a substituted naphthyl group, an ethenyl group, a 2-phenylethenyl group, a 9-anthryl group or a hetero ring; Rrepresents a hydrogen atom, a methyl group or a phenyl group.)