73051-88-4Relevant academic research and scientific papers
Divergent α-functionalization of cyclic amines: Via ring construction by molecular O2oxidized dearomatization and ring deconstruction by aromatization-driven C-C σ-bond cleavage
Ding, Zhanshuai,Ge, Chunyan,Hu, Fangzhi,Li, Shuai-Shuai,Li, Xinyao,Wang, Liang,Xu, Lubin
supporting information, p. 5535 - 5541 (2021/08/16)
An efficient approach to achieve the divergent α-C(sp3)-H functionalization of cyclic amines through a rationally designed ring construction and ring deconstruction strategy was developed. A variety of spiro cyclohexadienone decorated cyclic amines were o
Study on the scope of tert-amino effect: New extensions of type 2 reactions to bridged biaryls
Bottino, Paola,Dunkel, Petra,Schlich, Michele,Galavotti, Lorenzo,Deme, Ruth,Regdon Jr., Geza,Benyei, Attila,Pintye-Hodi, Klara,Ronsisvalle, Giuseppe,Matyus, Peter
, p. 1033 - 1041 (2014/01/06)
Thermal isomerization of aminomethyl- or oxygen-bridged biphenyl systems possessing dicyanovinyl and sec-amino groups in ortho- and ortho0-positions was investigated. Both systems underwent cyclization via tert-amino effect. Thus, 2-(2-{[2-(sec-amino)benz
An efficient microwave-assisted solvent-free synthesis of pyrido-fused ring systems applying the tert-amino effect
Kaval, Nadya,Halasz-Dajka, Beata,Vo-Thanh, Giang,Dehaen, Wim,Van Der Eycken, Johan,Mátyus, Péter,Loupy, André,Van Der Eycken, Erik
, p. 9052 - 9057 (2007/10/03)
Significant improvements in the synthesis of pyrido-fused heterocycles were observed when performing the reaction under solvent-free conditions, applying the tert-amino effect as the key ring closure methodology. An unexpected cyclization of ortho-(1′-aza
Neighbourgroup Participation with the Dehydrogenation of Cyclic Amines of the o-Substituted Aniline Type
Moehrle,Mehrens
, p. 1369 - 1378 (2007/10/03)
The 2-Aminobenzylalcohols 1a - c produced with mercury-edta dehydrogenation the lactams 6a - c; the pipecoline 2b yielded the benzoxazine 3b indicating the participation of the nucleophilic hydroxymethyl group. The 2-aminobenzaldehydes showed a different behaviour in dependence on the ring size of the amine part: 7a, b led - via intermediate reaction of the hemiaminal 9 with the electrophilic formyl function - to the lactams 11a, b, while 7c gave rise to the aminoaldehyde 12 as major product and similarly the pipecoline 15 to the aminoketone 16. From 2′-(4-morpholinyl)-acetophenone (22) were received the lactam 31 and the aminoethanol 32, both by a twofold dehydrogenation.
