87067-06-9Relevant academic research and scientific papers
A Catalyzed Aerobic Intramolecular C-O Bond Formation: Facile Access to Ring-Fused Dihydrobenzoxazine Derivatives
Shang, Xiao-Jie,Liu, Zhong-Quan
, p. 4693 - 4697 (2017)
A catalyst comprising of catalytic cobalt(II) acetate/copper(II) acetate/ dl -tyrosine with oxygen as the oxidant allows aerobic intramolecular C-O bond construction in [2-(pyrrolidin-1-yl)phenyl]methanol by free-radical promoted intramolecular selective functionalization of an (sp 3)C-H bond by the alcohol, thus providing an environmentally friendly approach to 5 H -benzo[ d ]pyrrolo[2,1- b ][1,3]oxazine derivatives.
Hexafluoroisopropanol-Mediated Redox-Neutral α-C(sp3)-H Functionalization of Cyclic Amines via Hydride Transfer
Shen, Yao-Bin,Wang, Lin-Xuan,Sun, Yun-Ming,Dong, Feng-Ying,Yu, Liping,Liu, Qing,Xiao, Jian
, p. 1915 - 1926 (2020/02/04)
Hexafluoroisopropanol has been demonstrated as the versatile promoter for redox-neutral α-C(sp3)-H functionalization of cyclic amines via the cascade [1,5]-hydride transfer/cyclization strategy. A wide range of cyclic amines are functionalized
N-Alkylation-Initiated Redox-Neutral [5 + 2] Annulation of 3-Alkylindoles with o-Aminobenzaldehydes: Access to Indole-1,2-Fused 1,4-Benzodiazepines
Wang, Shuai,Shen, Yao-Bin,Li, Long-Fei,Qiu, Bin,Yu, Liping,Liu, Qing,Xiao, Jian
supporting information, p. 8904 - 8908 (2019/11/19)
Described herein is an unprecedented N-Alkylation-initiated redox-neutral [5 + 2] annulation of 3-Alkylindoles with o-Aminobenzaldehydes via a cascade N-Alkylation/dehydration/[1,5]-hydride transfer/Friedel-Crafts alkylation sequence. A series of indole-1,2-fused 1,4-benzodiazepines are facilely constructed in moderate to good yields in one step. This protocol features excellent regioselectivity, metal-free conditions, high step economy, and wide substrate scope.
Efficient construction of tetrahydroquinolines: Via fluorinated alcohol mediated cascade [1,5]-hydride transfer/cyclization
Chen, Chunqi,Xu, Lubin,Wang, Liang,Li, Shuai-Shuai
, p. 7109 - 7114 (2018/10/23)
An environmentally benign cascade redox-neutral process was developed for the efficient construction of pharmaceutically significant spirocyclic tetrahydro-quinolines via a 3-step cascade Knoevenagel condensation/[1,5]-hydride transfer/cyclization, which features green and additive-free conditions, wide substrate scope, and high step- and atom-economy.
Intramolecular redox-triggered C-H functionalization
Jurberg, Igor D.,Peng, Bo,Woestefeld, Eckhard,Wasserloos, Maximilian,Maulide, Nuno
supporting information; experimental part, p. 1950 - 1953 (2012/04/04)
Sacrifice for the team: A one-pot method achieves remote functionalization at the α-position of an amine moiety through the sacrificial reduction of a neighboring group. The process takes advantage of an intramolecular redox reaction, thereby avoiding the need for any external oxidants. This method was applied to a concise five-step total synthesis of indolizidine 167B.
An efficient microwave-assisted solvent-free synthesis of pyrido-fused ring systems applying the tert-amino effect
Kaval, Nadya,Halasz-Dajka, Beata,Vo-Thanh, Giang,Dehaen, Wim,Van Der Eycken, Johan,Mátyus, Péter,Loupy, André,Van Der Eycken, Erik
, p. 9052 - 9057 (2007/10/03)
Significant improvements in the synthesis of pyrido-fused heterocycles were observed when performing the reaction under solvent-free conditions, applying the tert-amino effect as the key ring closure methodology. An unexpected cyclization of ortho-(1′-aza
