7306-39-0Relevant articles and documents
Cobalt-Catalyzed Aerobic Oxidative Cleavage of Alkyl Aldehydes: Synthesis of Ketones, Esters, Amides, and α-Ketoamides
Li, Tingting,Hammond, Gerald B.,Xu, Bo
supporting information, p. 9737 - 9741 (2021/05/31)
A widely applicable approach was developed to synthesize ketones, esters, amides via the oxidative C?C bond cleavage of readily available alkyl aldehydes. Green and abundant molecular oxygen (O2) was used as the oxidant, and base metals (cobalt and copper) were used as the catalysts. This strategy can be extended to the one-pot synthesis of ketones from primary alcohols and α-ketoamides from aldehydes.
Copper catalyzed arylation/C-C bond activation: An approach toward α-aryl ketones
He, Chuan,Guo, Sheng,Huang, Li,Lei, Aiwen
supporting information; scheme or table, p. 8273 - 8275 (2010/08/03)
An efficient arylation/C-C activation process was discovered. -Diketones with aryl halides (aryl iodides and aryl bromides) could undergo reaction smoothly in the presence of Cu(I) or Cu(II) salts in DMSO using K3 PO4 3H2 O without ligands. The role of H2 O was unprecedented, which assisted the C-C activation. Various -aryl ketones could be efficiently synthesized by this novel method. In situ monitoring of the formation of KOAc and experimentation relating to "a classic diagnostic technique for the participation of radical anion intermediates" revealed the preliminary mechanistic information for the reaction. This method is simple, general, and practical which complemented the classic method for the rapid construction of C-C bonds to a carbonyl moiety.
THIAZOLE-2-CARBOXAMIDE DERIVATIVES FOR USE AS HPPAR AGONISTS IN THE TREATMENT OF I.A. DYSLIPIDEMIA
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Page/Page column 9, (2010/02/11)
A compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof is claimed for use as a selective dual agonist of PPAR alpha and gamma.
Enamine oxidations. 2. Selective oxidative cleavage of β,β-disubstituted enamines using alumina supported permanganate. Synthesis of one-carbon dehomologated carbonyl compounds from enamines
Harris, Clifford E.,Chrisman, William,Bickford, Sally A.,Lee, Lawrence Y.,Torreblanca, Antonia E.,Singaram, Bakthan
, p. 981 - 984 (2007/10/03)
Treatment of β,β-disubstituted enamines with potassium permanganate supported on neutral alumina leads to a mild and selective oxidative cleavage reaction which produces ketones and formamides. The ketones can be isolated in high yield and purity by a simple workup procedure. The oxidizing agent is selective and preferentially oxidizes an enamine carbon-carbon double bond in the presence of a distal carbon-carbon double bond. Other functional groups unaffected by this reagent include nitriles, secondary alcohols, and alkynes allowing a wide range of potentially selective oxidations.
ALLYL- AND BENZYLSTANNANES, NEW REAGENTS IN TERPENIC SYNTHESIS
Andrianome, M.,Haeberle, K.,Delmond, B.
, p. 1079 - 1088 (2007/10/02)
Terpenic allyl- and benzylstannanes are easily prepared from unsaturated terpene hydrocarbons by metallation followed by quenching with trialkyltin chloride.An isomerization of unsaturated terpenes via allyltin compounds is reported, by which (+)-α-pinene has been converted into (+)-β-pinene.A regioselective acylation of allyl- and benzylstannanes are realized by a rhodium-catalyzed coupling with acyl halides.Mono- and sesquiterpenoid ketones which play an important role in the fragrance industry can be obtained.Hydroxylation and oxidation of terpene hydrocarbons via allyl- and benzylstannanes are also reported.
Regioselective Acylation of Terpene Hydrocarbons via Allyl- and Benzyltin Derivatives
Andrianome, M.,Delmond, B.
, p. 542 - 545 (2007/10/02)
Regioselective acylation of allyl- and benzylstannane derivatives derived from unsaturated terpene hydrocarbons are realized by a rhodium-catalyzed coupling with acyl halides.Mono- and sesquiterpenoid ketones which play an important role in the fragrance
