73088-11-6

Usage

General Description

2-(2-chloro-4-nitrophenyl)acetic acid is a chemical compound with the molecular formula C8H6ClNO4. It is a derivative of acetic acid and contains a chloro and nitro group attached to a phenyl ring. 2-(2-chloro-4-nitrophenyl)acetic acid is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various compounds. It has also been studied for its potential anti-inflammatory and analgesic properties. The presence of the chloro and nitro groups make it a versatile intermediate for the synthesis of various pharmaceutical and agrochemical products. Additionally, it can be used as a reagent in organic reactions to introduce the phenylacetic acid functionality into molecules.

Upstream product

• 99-54-7 3,4-dichloronitrobenzene 
• 73088-10-5 2-(2-chloro-4-nitro-phenyl)-malonic acid dimethyl ester 

Downstream Products

• 1192310-25-0 2-(2-chloro-4-nitrophenyl)-N-methoxyacetamide 
• 1192310-28-3 6-(2-chloro-4-nitrophenyl)-8-methoxy-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one 
• 1192310-29-4 6-(2-chloro-4-nitrophenyl)-2-(2-(dimethylamino)ethylamino)-8-methoxypyrido[2,3-d]pyrimidin-7(8H)-one 
• 1192310-24-9 6-(4-amino-2-chlorophenyl)-2-(2-(dimethylamino)ethylamino)-8-methoxypyrido[2,3-d]pyrimidin-7(8H)-one 
• 69395-15-9 2-(2-chloro-4-nitro-phenyl)-ethanol 

Relevant academic research and scientific papers

RAF INHIBITORS

The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are inhibitors or kinases such as Raf, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of

Improved raf inhibitors

The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are inhibitors or kinases such as Raf, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.

Therapeutic modulation of PPARgamma activity

Modulators of PPARγ activity are used in methods of treating and/or preventing conditions such as osteoporosis, Alzheimer's disease, psoriasis and acne, and cancer.

Use of EP4 receptor ligands in the treatment of IL-6 involved diseases

Methods of treating IL-6 involved diseases with EP4 receptor ligands, including EP4 receptor antagonists. Assays to determine the effect of test compounds on PGE2-induced whole blood cells activation.

Compounds for the modulation of PPARgamma activity

Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity.

EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS

The invention features a method of treating rheumatoid arthritis in a mammal comprising administering an agent that inhibits prostaglandin EP4 receptor (EP4) activity. Also featured is a method of identifying agents that selectively inhibit EP4 activity in vivo.