730951-40-3Relevant academic research and scientific papers
Quinazolin-4(3H)-one based agents bearing thiadiazole-urea: Synthesis and evaluation of anti-proliferative and antiangiogenic activity
Faraji, Aram,Motahari, Rasoul,Hasanvand, Zaman,Oghabi Bakhshaiesh, Tayebeh,Toolabi, Mahsa,Moghimi, Setareh,Firoozpour, Loghman,Boshagh, Mohammad Amin,Rahmani, Roya,Ketabforoosh, Shima H.M.E.,Bijanzadeh, Hamid Reza,Esmaeili, Rezvan,Foroumadi, Alireza
, (2021/01/04)
A series of quinazolin-4(3H)-one based agents containing thiadiazole-urea were designed, synthesized, and biologically evaluated. The proliferation rate of PC3 cells was moderately reduced by compound 9f (IC50 = 17.7 μM)which was comparable with sorafenib (IC50 = 17.3 μM). There was also a significant reduction in the number of HUVEC cells, when they were exposed to compound 9y (IC50 = 6.1 μM). To test the potential of compounds in inducing apoptosis, Annexin V-FITC/propidium iodide double staining assay was used. After the treatment of HUVEC cells with 9f, they underwent apoptotic effects. A substantial effort was dedicated to gathering comprehensive data across CAM assay. These data showed that 9f moderately inhibits the growth of corresponding blood vessels. Finally, the outcomes of Western blotting proposed a mechanism of action, by which the phosphorylation of VEGFR-2 is inhibited by compounds 9f and 9y.
QUINAZOLINE BASED RESPIRATORY SYNCYTIAL VIRUS INHIBITORS
-
Page/Page column 53, (2015/05/19)
Compounds of Formula (I), wherein R1, R2, R3, R4 and n are defined herein, are useful as inhibitors of RSV.
BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF GLYTL MEDIATED DISORDERS
-
Page/Page column 91, (2011/02/24)
The present invention relates to benzoxazinone derivatives, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in treating disorders mediated by GlyT1, including neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder.
A General synthetic procedure for 2-chloromethyl-4(3H)-quinazolinone derivatives and their utilization in the preparation of novel anticancer agents with 4-anilinoquinazoline scaffolds
Li, Hong-Ze,He, Hai-Yun,Han, Yuan-Yuan,Gu, Xin,He, Lin,Qi, Qing-Rong,Zhao, Ying-Lan,Yang, Li
experimental part, p. 9473 - 9485 (2011/02/27)
In our ongoing research on novel anticancer agents with 4-anilinoquinazoline scaffolds, a series of novel 2-chloromethyl-4(3H)- quinazolinones were needed as key intermediates. An improved one-step synthesis of 2-chloromethyl-4(3H)-quinazolinones utilizin
Regioselective Suzuki-Miyaura reaction: Application to the microwave-promoted synthesis of 4,7-diarylquinazolines
Kabri, Youssef,Verhaeghe, Pierre,Gellis, Armand,Vanelle, Patrice
scheme or table, p. 2949 - 2961 (2010/09/03)
New diarylquinazolines displaying pharmaceutical potential were synthesized in high yields from 4,7-dichloro-2-(2-methylprop-1-enyl)-6-nitroquinazoline by using microwave-promoted regioselective Suzuki-Miyaura cross-coupling reactions.
