73097-51-5

Usage

Uses

Used in Pharmaceutical Industry:
3-Amino-4-methylaminomethylsulfonylbenzene is used as an intermediate in the synthesis of anti-inflammatory drugs. Its unique chemical structure allows it to be a key component in the development of medications that help reduce inflammation and alleviate pain.
Used in Organic Chemistry:
3-Amino-4-methylaminomethylsulfonylbenzene is used as a building block in the creation of other organic compounds. Its versatile structure makes it a valuable precursor for the synthesis of various chemical products, contributing to the advancement of organic chemistry.
Safety Precautions:
It is important to handle 3-Amino-4-methylaminomethylsulfonylbenzene with care, as it can be harmful if it comes into contact with the skin, eyes, or if it is ingested. Proper safety measures should be taken to minimize the risk of exposure and ensure the safe use of this chemical compound in various applications.

Upstream product

• 30388-44-4 methyl 4-methyl-amino-3-nitrophenyl sulfone 
• 98-57-7 4-chlorophenyl methyl sulfone 
• 97-07-4 1-chloro-4-methanesulfonyl-2-nitrobenzene 
• 453-72-5 1-fluoro-4-methanesulfonyl-2-nitrobenzene 

Downstream Products

• 1191924-20-5 C₂₂H₁₉Cl₂N₅O₂S 

Relevant academic research and scientific papers

Design, synthesis, anticancer activity, molecular docking and ADME studies of novel methylsulfonyl indole-benzimidazoles in comparison with ethylsulfonyl counterparts

Cancer poses a world-wide healthcare problem, demanding selective and effective therapy protocols. To address that, a vast amount of therapeutic candidates are being investigated in the field of medicinal chemistry. Accordingly, indole-benzimidazole structures have recently gained considerable interest because of their anticancer properties and estrogen receptor (ER) modulatory actions. In this study, novel methylsulfonyl indole-benzimidazole derivatives have been synthesized upon substitution of respectively the first (R1) and fifth (R2) positions of benzimidazole and indole groups. Structure and activity relationships were then studied via1H NMR, 13C NMR, mass spectral and in silico docking analyses, as well as cell viability measurements. We found that the compounds exhibited substantial affinity levels towards ER alpha (ERα). In addition, the correlation analysis of cytotoxicity profiles between ethyl- and methyl-sulfonyl indole-benzimidazoles revealed a collection of effective and consistent R1 and R2 substitutions. However, for some candidate derivatives, distinctive cytotoxicity levels and varying viability versus ERα affinity correlations were observable across the studies, suggesting that the sulfonyl side chain modifications themselves can also influence the ERα binding levels. These results demonstrated that our novel methylsulfonyl indole-benzimidazole derivatives, similar to their ethylsulfonyl counterparts, exhibit anticancer effects with potential estrogen receptor modulatory actions. This journal is

C2-Selective Branched Alkylation of Benzimidazoles by Rhodium(I)-Catalyzed C-H Activation

Herein, we report a Rh(I)/bisphosphine/K3PO4 catalytic system allowing for the first time the selective branched C-H alkylation of benzimidazoles with Michael acceptors. Branched alkylation with N,N-dimethyl acrylamide was successfully applied to the alkylation of a broad range of benzimidazoles incorporating a variety of N-substituents and with both electron-rich and -poor functionality displayed at different sites of the arene. Moreover, the introduction of a quaternary carbon was achieved by alkylation with ethyl methacrylate. The method was also shown to be applicable to the C2-selective branched alkylation of azabenzimidazoles.

Substituted Fused Imidazole Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof

Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and methods of use in treating inflammation are provided. The substituted fused imidazole derivatives may control the activity or the amount or both the activity and the amount of heme-oxygenase.