7310-94-3

Basic information

• Product Name: 2-CHLORO-5-HYDROXYBENZALDEHYDE
• Synonyms: 2-CHLORO-5-HYDROXYBENZALDEHYDE;Benzaldehyde, 2-chloro-5-hydroxy-
• CAS NO: 7310-94-3
• Molecular Formula: C₇H₅ClO₂
• Molecular Weight: 156.57
• Product Categories: Aromatic Aldehydes & Derivatives (substituted)
• Mol File: 7310-94-3.mol

Chemical Properties

• Melting Point: 110.5-111.5 °C
• Boiling Point: 272.4±20.0 °C(Predicted)
• Appearance: /
• Density: 1.404±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 8.80±0.18(Predicted)
• CAS DataBase Reference: 2-CHLORO-5-HYDROXYBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-HYDROXYBENZALDEHYDE(7310-94-3)
• EPA Substance Registry System: 2-CHLORO-5-HYDROXYBENZALDEHYDE(7310-94-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 7310-94-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-5-hydroxybenzaldehyde is used as a reagent for the synthesis of p38 inhibitors, which are crucial in the treatment of chronic obstructive pulmonary disease (COPD). These inhibitors help regulate the immune response and reduce inflammation associated with the disease.
Used in Agricultural Industry:
In the agricultural sector, 2-Chloro-5-hydroxybenzaldehyde is utilized in the preparation of halogenated analogs of L-meta-tyrosine, a biodegradable herbicide. This herbicide is effective in controlling weed growth without causing significant harm to the environment.
Used in Chemical Synthesis:
2-Chloro-5-hydroxybenzaldehyde may also serve as a starting material in the synthesis of chlorinated phenylephrine, a compound with potential applications in the pharmaceutical and chemical industries. Its unique structure allows for further modification and development of new compounds with specific properties and uses.

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 876299-47-7 4-chloro-3-(hydroxymethyl)phenol 
• 42454-06-8 2-nitro-5-hydroxybenzaldehyde 
• 59-50-7 4-Chloro-3-methylphenol 

Downstream Products

• 108009-51-4 4-chloro-3-(4-morpholinylmethyl)phenol 
• 876338-19-1 3-(6-{[2-(aminomethyl)phenyl]thio}[1,2,4]triazolo[4,3-a]pyridin-3-yl)-4-chlorophenol 
• 876299-52-4 4-chloro-3-(6-{[2-(hydroxymethyl)phenyl]thio}[1,2,4]triazolo[4,3-a]pyridin-3-yl)phenol 
• 876299-49-9 3-(6-bromo[1,2,4]triazolo[4,3-a]pyridin-3-yl)-4-chlorophenol 
• 1027538-90-4 1-{3-tert-butyl-1-[3-(2-hydroxyethoxy)phenyl]-1H-pyrazol-5-yl}-3-(2-{[3-(2-chloro-5-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)urea 
• 1344738-35-7 1-(3-tert-butyl-1-{3-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-pyrazol-5-yl)-3-(2-{[3-(2-chloro-5-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)urea 

Relevant articles and documents

Facile p-toluenesulfonic acid-promoted para-selective monobromination and chlorination of phenol and analogues

para-Regioselective bromination of phenol and analogues, promoted by p-toluenesulfonic acid, is achieved in high to excellent yields at room temperature with N-bromosuccinimide. Chlorination with N-chlorosuccinimide and catalysed by p-toluenesulfonic acid also gives para-chlorinated phenol analogues in good yields at room temperature. para-Bromination of phenol, promoted by p-toluenesulfonic acid, is achieved in excellent yields at room temperature with N-bromosuccinimide. p-Toluenesulfonic acid is also effective as a promoter of para-chlorination with N-chlorosuccinimide.

Triazolopyridinylsulfanyl derivatives as p38 MAP kinase inhibitors

A compound of formula (I), or a pharmaceutically acceptable salt and/or solvate (including hydrate) thereof; and the use of a compound of formula (I) in the treatment of a TNF-mediated disease, disorder, or condition, or a p38-mediated disease, disorder, or condition, in particular the allergic and non-allergic airways diseases, more particularly obstructive or inflammatory airways diseases, preferably chronic obstructive pulmonary disease.