7310-95-4Relevant articles and documents
Dinucleating Ligand Platforms Supporting Indium and Zinc Catalysts for Cyclic Ester Polymerization
Kremer, Alexandre B.,Osten, Kimberly M.,Yu, Insun,Ebrahimi, Tannaz,Aluthge, Dinesh C.,Mehrkhodavandi, Parisa
, p. 5365 - 5374 (2016)
The synthesis of the first alkoxide-bridged indium complex supported by a chiral dinucleating ligand platform (1), along with its zinc analogue (2), is reported. Both complexes are synthesized in a one-pot reaction starting from a chiral dinucleating bis(diamino)phenolate ligand platform, sodium ethoxide, and respective metal salts. The dinucleating indium analogue (7) based on an achiral ligand backbone is also reported. Indium complexes bearing either the chiral or achiral ligand catalyze the ring-opening polymerization of racemic lactide (rac-LA) to afford highly heterotactic poly(lactic acid) (PLA; Pr > 0.85). The indium complex bearing an achiral ligand affords essentially atactic PLA from meso-LA. The role of the dinucleating ligand structure in catalyst synthesis and polymerization activity is discussed.
A carbonothioate-based highly selective fluorescent probe with a large Stokes shift for detection of Hg2+
Xu, Jing,Xu, Zhenghe,Wang, Zuokai,Liu, Caiyun,Zhu, Baocun,Wang, Xiuru,Wang, Kun,Wang, Jiangting,Sang, Guoqing
, p. 219 - 224 (2018)
Mercury (Hg) is one of the heavy metal pollutants in the environment. Even a very small amount of mercury can cause serious harm to human beings. Herein, we reported a new carbonothioate-based fluorescent probe for the detection of Hg2+ without interference from other metal ions. This probe possessed a very large Stokes shift (192?nm), which could improve the detection sensitivity by minimizing the interferences resulted from self-absorption or auto-fluorescence. With the addition of Hg2+ to the probe solution, considerable fluorescence enhancement was observed. Additionally, the Hg2+ concentration of 0–16?μM and fluorescence intensity showed a good linear relationship (y?=?22106×?+?53108, R2?=?0.9955). Finally, the proposed probe was used to detect Hg2+ in real water samples, and its result was satisfactory. Therefore, our proposed probe would provide a promising method for the determination of Hg2+ in the environment.
Oxidation of 2,6-Bis(hydroxymethyl)phenols to 2-Hydroxyisophthalaldehydes by MnO2
Taniguchi, Shozo
, p. 2683 - 2684 (1984)
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A detailed study on the interaction of a novel water-soluble glycine bridged zinc(II) Schiff base coordination polymer with BSA: Synthesis, crystal structure, molecular docking and cytotoxicity effect against A549, Jurkat and Raji cell lines
Asadi, Zahra,Golchin, Maryam,Eigner, Vaclav,Dusek, Michal,Amirghofran, Zahra
, p. 50 - 60 (2017)
A novel water-soluble glycine bridged zinc(II) Schiff base coordination polymer was synthesized by the condensation of 2,6-diformyl-4-methylphenol, glycine, and zinc(II) chloride. The complex was characterized by 1HNMR, FT-IR, elemental analyses and X-ray crystallography. The polymeric complex was built up of two glycine-bridged Zn/L moieties, where L denotes the Schiff base containing 2,6-diformyl-4-methylphenol and glycine in 1:1?M ratio. The carboxylic group of L was coordinated to the Zn atoms of the neighboring moieties; thus each Zn center was five-coordinated. The interaction between polymeric Zn(II) complex and bovine serum albumin (BSA) was studied by UV–Vis, fluorescence, and synchronous fluorescence spectroscopic techniques. By considering the sign and values of the thermodynamic parameters (ΔH and ΔS), it is clear that the binding between BSA and complex was exothermic and entropy-driven and electrostatic interactions between the complex and BSA was supposed. Site-selective binding studies revealed that the complex were mainly located in the region of site II (subdomain IIIA) in BSA. From the synchronous fluorescence spectroscopic studies, it is concluded that complex could bind to tyrosine and tryptophan residues simultaneously. The Kb values indicated a high binding affinity of the complex to BSA. In vitro anticancer activity of the polymeric Zn(II) complex was evaluated against A549, Jurkat, and Raji cell lines by MTT assay. The complex was remarkably active against the cell lines and can be a good candidate for an anticancer therapy. Theoretical docking studies were performed to further investigate the BSA binding interactions.
Investigation of the complex structure, comparative DNA-binding and DNA cleavage of two water-soluble mono-nuclear lanthanum(III) complexes and cytotoxic activity of chitosan-coated magnetic nanoparticles as drug delivery for the complexes
Asadi, Zahra,Nasrollahi, Neda,Karbalaei-Heidari, Hamidreza,Eigner, Vaclav,Dusek, Michal,Mobaraki, Nabiallah,Pournejati, Roya
, p. 125 - 135 (2017)
Two water-soluble mono-nuclear macrocyclic lanthanum(III) complexes of 2,6-diformyl-4-methylphenol with 1,3-diamino-2-propanol (C1) or 1,3-propylenediamine (C2) were synthesized and characterized by UV–Vis, FT-IR, 13C and 1H NMR spectroscopy and elemental analysis. C1 complex was structurally characterized by single-crystal X-ray diffraction, which revealed that the complex was mononuclear and ten-coordinated. The coordination sites around lanthanum(III) were occupied with a five-dentate ligand, two bidentate nitrates, and one water molecule. The interaction of complexes with DNA was studied in buffered aqueous solution at pH 7.4. UV–Vis absorption spectroscopy, emission spectroscopy, circular dichroism (CD) and viscometric measurements provided clear evidence of the intercalation mechanism of binding. The obtained intrinsic binding constants (Kb) 9.3 × 103 and 1.2 × 103 M? 1 for C1 and C2, respectively confirmed that C1 is better intercalator than C2. The DNA docking studies suggested that the complexes bind with DNA in a groove binding mode with the binding affinity of C1 > C2. Moreover, agarose gel electrophoresis study of the DNA-complex for both compounds revealed that the C1 intercalation cause ethidium bromide replacement in a competitive manner which confirms the suggested mechanism of binding. Finally, the anticancer experiments for the treated cancerous cell lines with both synthesized compounds show that these hydrophilic molecules need a suitable carrier to pass through the hydrophobic nature of cell membrane efficiently.
Transition metal complexes of 2, 6-di ((phenazonyl-4-imino) methyl)-4-methylphenol: Structure and biological evaluation
Liu, Hongyan,Shi, Xiaoyan,Xu, Min,Li, Zhengpeng,Huang, Liang,Bai, Decheng,Zeng, Zhengzhi
, p. 1638 - 1647 (2011)
A symmetric ligand 2, 6-di ((phenazonyl-4-imino)methyl)-4-methylphenol (Dpmp) and its cobalt dinuclear complex (Co2(Dpmp) 2(NO3)2(H2O)2·NO3· EtOH, (1) and zinc mononuclear complex Zn(Dpmp)(NO3)2, (2) have been prepared. The crystal structures were determined by single-crystal X-ray diffraction. The biological activity has been evaluated by examining their anti-oxidative activity and ability to bind to bovine serum albumin (BSA) and calf-thymus DNA (CT DNA) with UV-vis absorption, fluorescence, viscosity measurements and circular dichroism (CD) spectroscopies. The complexes exhibit good binding propensity to BSA and CT DNA. Both 1 and 2 have been found to promote cleavage of pUC19 DNA in the absence of any reducing agent. Antioxidant tests in vitro show the compounds possess significant antioxidant activity against superoxide and hydroxyl radicals.
Examination of structure-activity relationship of new n-acylhydrazones
Coman, Anca G.,Paun, Anca,Popescu, Codru?a C.,Hadade, Niculina D.,Hanganu, Anamaria,M?d?lan, Augustin M.,Matache, Mihaela
, p. 109 - 114 (2021/02/05)
In this study we describe synthesis and characterization of new substituted hydroxy-bis-N-acylhydrazones in order to investigate influence of their switching emission properties, according to the nature of the substituent. The fluorescence of the compounds depended on the solvent used (organic or aqueous). The different emission colors observed could be explained by conformation modifications.
Synthesis and study of new photochromic spiropyrans modified with carboxylic and aldehyde substituents
Ozhogin, Ilya V.,Chernyavina, Valentina V.,Lukyanov, Boris S.,Malay, Vasily I.,Rostovtseva, Irina A.,Makarova, Nadezhda I.,Tkachev, Valery V.,Lukyanova, Maria B.,Metelitsa, Anatoly V.,Aldoshin, Sergey M.
, p. 409 - 416 (2019/07/04)
Three new photochromic spiropyrans containing a carboxylic group in the indoline fragment and an aldehyde substituent in the [2H]-chromene moiety were synthesized. The structure of the compounds obtained was studied using 1H and 13C NMR, IR and elemental analysis. Single crystal X-ray analysis was used to refine the molecular structure of 8′-formyl-1,3,3,6′-tetramethyl-spiro[indoline-2,2′-2H-chromene]-5-carboxylic acid. It was found out that in the solid state the molecules of that compound are arranged in dimeric associates due to the formation of intermolecular hydrogen bonds between carboxylic groups of two adjacent molecules. All the spiropyrans were shown to be photochromic with the lifetimes of the open forms in the range of 1.5–46.0 s.
