73101-90-3

Upstream product

• 73101-87-8 5-ethyl-8-oxo-5,8-dihydrofuro<3,2-b><1,8>naphthyridine-7-carboxylic acid 
• 73101-78-7 3-ethoxy-6-nitro-2-picoline 
• 6652-01-3 3-ethoxy-2-methyl-pyridine 
• 95837-11-9 5-amino-2,3-dihydrofuro<3,2-b>pyridine 
• 73101-88-9 ethyl 5-ethyl-3-hydroxy-8-oxo-2,3,5,8-tetrahydrofuro<3,2-b><1,8>naphthyridine-7-carboxylate 
• 73101-89-0 ethyl 3-chloro-5-ethyl-8-oxo-2,3,5,8-tetrahydrofuro<3,2-b><1,8>naphthyridine-7-carboxylate 
• 95863-77-7 diethyl (2,3-dihydrofuro<3,2-b>pyridin-5-yl)aminomethylenemalonate 
• 79905-34-3 6-benzyloxy-7-(2,2-diethoxyethyl)-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid 
• 73101-83-4 ethyl 6-ethoxy-1-ethyl-7-formyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 
• 73101-84-5 ethyl 1-ethyl-7-formyl-6-hydroxy-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 
• 73101-82-3 ethyl 6-ethoxy-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 
• 73101-81-2 ethyl 6-ethoxy-4-hydroxy-7-methyl-1,8-naphthyridine-3-carboxylate 
• 28310-22-7 [(3-hydroxypyridin-2-yl)methyl]trimethylazanium iodide 
• 79905-33-2 ethyl 6-benzyloxy-7-(2-dimethylaminovinyl)-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 

Relevant academic research and scientific papers

Synthesis of antimicrobial agents. VI. Studies on the synthesis of furo[3,2-b][1,8]naphthyridine derivatives

As a part of our search for new antibacterial agents, 5-ethyl-8-oxo-5,8-dihydrofuro[3,2-b][1,8]naphthyridine-7-carboxylic acid and its 2,3-dihydrofuro derivative, the 4-aza analogue of droxacin, were synthesized and their antibacterial activities were tested. Both compounds exhibited high antibacterial activities and a broad antibacterial spectrum. In an attempt to find a suitable method for industrial-scale synthesis of these compounds, several methods for the furan ring cyclization of 6,7-disubstituted 1,8-naphthyridine-3-carboxylate derivatives were compared.

Furonaphthyridine compounds

2,3,5,8-Tetrahydrofuro- and 5,8-dihydrofuro[3,2-b]-1,8-naphthyridine compounds of the formula (I) STR1 wherein R1 represents an alkyl group having 1 to 6 carbon atoms and M represents a hydrogen atom, an alkali metal or an alkaline earth metal having anti-bacterial activity.