79905-33-2

Upstream product

• 83593-35-5 ethyl 6-benzyloxy-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-7-carboxylate 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 73101-78-7 3-ethoxy-6-nitro-2-picoline 
• 6652-01-3 3-ethoxy-2-methyl-pyridine 
• 73101-79-8 6-amino-3-ethoxy-2-picoline 
• 73101-80-1 diethyl (3-ethoxy-2-methylpyridin-6-yl)aminomethylenemalonate 
• 95837-13-1 ethyl 1-ethyl-6-hydroxy-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 
• 73101-81-2 ethyl 6-ethoxy-4-hydroxy-7-methyl-1,8-naphthyridine-3-carboxylate 
• 73101-82-3 ethyl 6-ethoxy-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 

Downstream Products

• 79905-34-3 6-benzyloxy-7-(2,2-diethoxyethyl)-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid 
• 73101-87-8 5-ethyl-8-oxo-5,8-dihydrofuro<3,2-b><1,8>naphthyridine-7-carboxylic acid 
• 73101-91-4 ethyl 5-ethyl-8-oxo-5,8-dihydrofuro<3,2-b><1,8>naphthyridine-7-carboxylate 
• 73101-90-3 5-ethyl-8-oxo-2,3,5,8-tetrahydrofuro<3,2-b><1,8>naphthyridine-7-carboxylic acid 

Relevant academic research and scientific papers

Synthesis of antimicrobial agents. VI. Studies on the synthesis of furo[3,2-b][1,8]naphthyridine derivatives

As a part of our search for new antibacterial agents, 5-ethyl-8-oxo-5,8-dihydrofuro[3,2-b][1,8]naphthyridine-7-carboxylic acid and its 2,3-dihydrofuro derivative, the 4-aza analogue of droxacin, were synthesized and their antibacterial activities were tested. Both compounds exhibited high antibacterial activities and a broad antibacterial spectrum. In an attempt to find a suitable method for industrial-scale synthesis of these compounds, several methods for the furan ring cyclization of 6,7-disubstituted 1,8-naphthyridine-3-carboxylate derivatives were compared.