7312-07-4Relevant academic research and scientific papers
Synthesis and studies of symmetric dibenzothienylcyclopentenes
Migulin, Vasily A.,Krayushkin, Michael M.,Barachevsky, Valery A.,Kobeleva, Olga I.,Novikov, Valentin V.,Lyssenko, Konstantin A.
, p. 584 - 598 (2015)
Various symmetric 5,5′-substituted dibenzo[b]thienylcyclopentenes were synthesized from the corresponding dibromide with a formation of new C-C, C-N, C-O, C-Si, and C-I bonds. The influence of the introduced substituent on the photochromic properties of t
AMINOISOXAZOLINE COMPOUNDS AS AGONISTS OF ALPHA7-NICOTINIC ACETYLCHOLINE RECEPTORS
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Paragraph 00347; 00348, (2017/05/19)
The present invention relates to novel aminoisoxazoline compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of α7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.
Covalent modification of 2′-deoxyuridine with two different molecular switches
Barrois, Sebastian,Beyer, Christoph,Wagenknecht, Hans-Achim
experimental part, p. 711 - 716 (2012/07/28)
Two different molecular switches, a spiropyran and a diarylethene, were attached synthetically to the 5-position of 2-de-oxyuridine. The diarylethene-modified nucleoside can be incorporated synthetically into DNA while preserving its characteristic photochromism. Georg Thieme Verlag Stuttgart · New York.
Diarylethene-modified nucleotides for switching optical properties in DNA
Barrois, Sebastian,Wagenknecht, Hans-Achim
scheme or table, p. 905 - 914 (2012/08/08)
Diarylethenes were attached to the 5-position of 2'-deoxyuridine in order to yield three different photochromic nucleosides. All nucleosides were characterized with respect to their absorption and photochromic properties. Based on these results, the most
COMPOUNDS, PREPARATIONS AND USES THEREOF
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, (2011/07/09)
The present invention provides novel compounds of the Formula (I), pharmaceutical compositions comprising such compounds and methods for using such compounds as agents or drugs for inhibiting perforin activity and for treating a subject at risk of or susc
Synthesis and photochromism of functionalized benzothiophene-based fulgides and fulgimides
Luyksaar,Migulin,Nabatov,Krayushkin
, p. 446 - 451 (2011/02/17)
Earlier unknown fulgides and the corresponding functionalized fulgimides containing a primary amino group were obtained. Their photochromism was examined using spectroscopic methods.
Sulfonamide compounds and medicinal use thereof
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, (2010/02/04)
A sulfonamide compound of the formula (I):R 1 --SO 2 NHCO--A--R 2 (I)wherein R 1 is alkyl, alkenyl, alkynyl and the like; A is an optionally substituted heteropolycyclic group except benzimidazolyl, indolyl, 4,7-dihydrobenzimidazolyl and 2,3-dihydrobenzoxazinyl; X is alkylene, oxa, oxa(lower)alkylene and the like; and R 2 is optionally substituted aryl, substituted biphenylyl and the like, a salt thereof and a pharmaceutical composition comprising the same. The sulfonamide compound is effective for the diseases treatable based on their blood sugar level-depressing activity, cGMP-PDE (especially PDE-V)-inhibiting activity, smooth muscle relaxing activity, bronchodilating activity, vasodilating activity, smooth muscle cell suppressing activity, and antiallergic activity.
Novel substituted 3H-1,2,3,5-oxathiadiazole 2-oxides useful as anthihyperglycemic agents
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, (2008/06/13)
This invention relates to novel substituted 3H-1,2,3,5-oxathiadiazole 2-oxides, to the processes for their preparation, to methods for using the compounds, and to pharmaceutical compositions thereof. The compounds have pharmaceutical properties which render them beneficial for the treatment of diabetes mellitus and associated conditions.
