7312-18-7

Usage

Uses

Used in Pharmaceutical Industry:
5-BROMOBENZO[B]THIOPHENE-2-CARBALDEHYDE is used as a key intermediate in the synthesis of biscationic, trypanocidal 1-benzofuran compounds. These compounds have demonstrated potential as therapeutic agents for the treatment of trypanosomiasis, a group of parasitic diseases caused by Trypanosoma species. The synthesis of these biscationic compounds leverages the reactivity of the aldehyde group in 5-BROMOBENZO[B]THIOPHENE-2-CARBALDEHYDE, allowing for the formation of new carbon-carbon bonds and the creation of diverse molecular structures with potential biological activity.
In addition to its application in the pharmaceutical industry, 5-BROMOBENZO[B]THIOPHENE-2-CARBALDEHYDE may also find use in other areas of chemical research and development, such as the synthesis of novel materials, dyes, and other specialty chemicals. Its unique structural features and reactivity make it a valuable starting material for the exploration of new chemical space and the development of innovative applications.

Upstream product

• 13771-72-7 (5-bromobenzo[b]thiophen-2-yl)methanol 
• 106-53-6 para-bromobenzenethiol 
• 7312-07-4 5-bromo-2-methylbenzothiophene 
• 4923-87-9 5-bromobenzo[b]thiophene 
• 68-12-2 N,N-dimethyl-formamide 
• 50-00-0 formaldehyd 
• 65523-60-6 (4-bromophenyl)(2-chloroallyl)sulfane 
• 13771-68-1 5-bromobenzo[b]thiophene-2-carboxylic acid ethyl ester 
• 93777-26-5 5-bromo-2-fluorobenzaldehyde 

Downstream Products

• 1391828-90-2 C₁₀H₆BrF₃OS 
• 38251-66-0 5-bromobenzo[b]thiophene-2-carbonitrile 

Relevant academic research and scientific papers

Benzimidazole derivative, benzothiophene derivative as well as preparation method and application of benzoimidazole derivative and benzothiophene derivative

The invention provides a benzimidazole derivative and a benzothiophene derivative. The benzimidazole derivative and the benzothiophene derivative respectively have structures shown in a formula (I) and a formula (IV). Experimental results show that the benzimidazole derivative and the benzothiophene derivative provided by the invention have good anti-tumor activity and can be used for preparing related tumor disease treatment medicines.

Catalytic Deprotonative α-Formylation of Heteroarenes by an Amide Base Generated in Situ from Tetramethylammonium Fluoride and Tris(trimethylsilyl)amine

Heteroarene formylations in DMF solution proceed in the presence of an amide base catalyst generated in situ from tetramethylammonium fluoride (TMAF) and tris(trimethylsilyl)amine (N(TMS)3). The reaction proceeds at room temperature and has an operationally simple procedure. Various heteroarenes, including benzothiophene, thiophene, benzothiazole, oxazole, and indole derivatives, can be formylated with high functional group tolerance.

Benzothiophene-flanked diketopyrrolopyrrole polymers: Impact of isomeric frameworks on carrier mobilities

Exploring new building blocks for solution-processable polymeric semiconductors has attracted much attention. We herein develop two isomeric benzothiophene-flanked diketopyrrolopyrrole polymers with different linkage positions and further systematically study the electronic structures, optical properties, and field-effect characteristics. Both polymers exhibit typical p-type transport characteristics with the highest mobility being up to 0.80 cm2 V-1 s-1. Our results suggest that the isomeric backbones for conjugated polymers greatly affect charge transport properties.

COMPOUNDS, PREPARATIONS AND USES THEREOF

The present invention provides novel compounds of the Formula (I), pharmaceutical compositions comprising such compounds and methods for using such compounds as agents or drugs for inhibiting perforin activity and for treating a subject at risk of or susc