7313-70-4Relevant articles and documents
Catalytic reactivity of new Ni(II), Cu(II) and Sn(II) complexes for decolorization of indigo carmine in aqueous solution, high efficiency of copper complex
Nassar, Amr Mohammad
, (2018)
A new Ni(II), Cu(II) and Sn(II) Schiff base complexes were synthesized in this work. The characterization of the new complexes is carried out by elemental analysis, FT-IR, UV–Visible, 1H NMR and 13C NMR spectroscopy, conductance analysis, magnetic measurements and thermal gravimetric analysis. It was found that the ligand behaves as a dibasic bidentate which coordinated to the metal center through two deprotonated hydroxyl groups to form tetrahedral complex with Ni(II) and octahedral complex with Cu(II). The ligand acts as neutral bidentate through azomethine nitrogen and thiazol sulfur to form octahedral complex with Sn(II). The synthesized complexes are evaluated as catalysts for oxidative degradation of indigo carmine dye using H2O2 as oxidant and the efficiency of the catalysts is determined. The copper complex shows the best catalytic action with efficiency 92.17% after 25?min.
Design, synthesis, characterization of water-soluble indophenine dyes and their application for dyeing of wool, silk and nylon fabrics
Cai, Jinfang,Chen, Weiguo,Cui, Zhihua,Jiang, Hua
, (2020)
In view of our continuing interests in application of quinoidal heterocyclic structure into textile dyestuffs, we report here the design and synthesis of four new water-soluble dyes D1-D4 that based on indophenine structure and bearing alkyl chains with different lengths. Their properties on geometry, electronic structure, solubility, thermal stability and absorption spectra have been well investigated. Then, the dyeing ability of D1-D4 is checked by application into dyeing of wool, silk and nylon fabrics and is compared with three commercial acid dyes. The effect of quinoidal coplanarity of indophenine backbone and alkyl substituents on dyeing performance has been revealed. Our study clearly demonstrates that the introduction of rigid quinoidal heterocyclic structure with high coplanarity as the chromophore backbone is an efficient method for the design of high-performance acid dyestuffs in terms of exhaustion, coloring strength and wet fastness.
CTAB-assisted ultrasonic synthesis, characterization and photocatalytic properties of WO3
Sánchez-Martíneza, Daniel,Gómez-Solísa,Torres-Martíneza, Leticia M.
, p. 165 - 172 (2015)
WO32D nanostructures have been prepared by ultrasound synthesis method assisted with CTAB using different molar ratios. The formation of monoclinic crystal structure of WO3was confirmed by X-ray powder diffraction (XRD). The characterization of the WO3samples was complemented by analysis of scanning electron microscopy (SEM), which revealed morphology mainly of rectangular nanoplates with a thickness of around 50 nm and length of 100-500 nm. Infrared spectroscopy (FT-IR) was used to confirm the elimination of the CTAB in the synthesized samples. The specific surface area was determinate by the BET method and by means of diffuse reflectance spectroscopy (DRS) it was determinate the band-gap energy (Eg) of the WO3samples. The photocatalytic activity of the WO3oxide was evaluated in the degradation reactions of rhodamine B (rhB) and indigo carmine (IC) under Xenon lamp irradiation. The highest photocatalytic activity was observed in the samples containing low concentration of CTAB with morphology of rectangular nanoplates and with higher surface area value than commercial WO3. Photodegradation of rhB and IC were followed by means of UV-vis absorption spectra. The mineralization degree of organic dyes by WO3photocatalyst was determined by total organic carbon analysis (TOC) reaching percentages of mineralization of 92% for rhB and 50% for IC after 96 h of lamp irradiation.
Isatin-5-sulfonamide inhibitor with inhibition effect on MLL (mixed lineage leukemia) key protein
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Paragraph 0037-0041; 0043, (2020/09/20)
The invention provides an application of a compound with isatin-5-sulfonamide as a parent nucleus to resistance to MLL (mixed lineage leukemia). The isatin-5-sulfonamide compound can be used for inhibiting activity of an MLL associated protein, namely, histone lysine methyltransferase DOT1L (disruptor of telomeric silencing 1-like). Therefore, the compound is probably used for preparing a small-molecule inhibitor for the MLL.
Highly sensitive and selective bioluminescence based ozone probes and their applications to detect ambient ozone
Nam, Younseok,Kim, Beom Seok,Shin, Injae
supporting information, p. 1128 - 1130 (2016/01/15)
Highly selective and sensitive bioluminescence based probes, which respond to ozone but not to other ROS, have been developed. These probes were used to determine ozone concentrations in environmental samples.
Catalytic effect of CTAB reverse micelles on the oxidation of indigo carmine by periodate
Nagalakshmi,Shyamala,Rao, P. V. Subba
, p. 351 - 355 (2015/05/05)
The kinetics of oxidation of indigo carmine by periodate has been investigated in the presence of CTAB reverse micellar medium. The reaction obeys first order kinetics with respect to each of the reactants. The reaction is markedly catalysed in the presence of CTAB reverse micelles as compared to in aqueous medium under identical conditions. The significant increase in rate is attributed to the special properties of the water pool of reverse micelles which are controlled by a W parameter where W = ([H2O]/[CTAB]). The specific rate constant, k3 {= k'/[IO4-] [H2O]} is found to be constant for all values of W > 4.4, implying that water is one of the reactants and is involved in the rate determining step. Such studies regarding the role of water cannot be obtained in conventional aqueous medium. The effect of CTAB has been analyzed using the Berezin pseudo-phase model.
Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors
Liu, Wei,Zhu, He-Min,Niu, Guo-Jun,Shi, En-Zhi,Chen, Jie,Sun, Bo,Chen, Wei-Qiang,Zhou, Hong-Gang,Yang, Cheng
, p. 292 - 302 (2014/01/17)
The Severe Acute Respiratory Syndrome (SARS) is a serious life-threatening and strikingly mortal respiratory illness caused by SARS-CoV. SARS-CoV which contains a chymotrypsin-like main protease analogous to that of the main picornavirus protease, 3CLpro. 3CLpro plays a pivotal role in the viral replication cycle and is a potential target for SARS inhibitor development. A series of isatin derivatives as possible SARS-CoV 3CL pro inhibitors was designed, synthesized, and evaluated by in vitro protease assay using fluorogenic substrate peptide, in which several showed potent inhibition against the 3CLpro. Structure-activity relationship was analyzed, and possible binding interaction modes were proposed by molecular docking studies. Among all compounds, 8k1 showed most potent inhibitory activity against 3CLpro (IC50 = 1.04 μM). These results indicated that these inhibitors could be potentially developed into anti-SARS drugs.
3,3-Diaryl-1,3-dihydroindol-2-ones as Antiproliferatives Mediated by Translation Initiation Inhibition
Natarajan, Amarnath,Fan, Yun-Hua,Chen, Han,Guo, Yuhong,Iyasere, Julia,Harbinski, Frederick,Christ, William J.,Aktas, Huseyin,Halperin, Jose A.
, p. 1882 - 1885 (2007/10/03)
A series of substituted 3,3-diphenyl-1,3-dihydroindol-2-ones was synthesized from the corresponding isatins. The compounds were studied for cell growth inhibition mediated by partial depletion of intracellular Ca 2+ stores that leads to phosphorylation of eIF2α. The diphenyloxindole (1) showed mechanism-specific antiproliferative activity that was comparable to known translation initiation inhibitors such as clotrimazole or troglitazone. SAR studies identified m'-tert-butyl and o-hydroxy substituted diphenyloxindole (25) as a lead compound for Ca2+-depletion-mediated inhibition of translation initiation.
A Kinetic Study of the Oxidation of Indigo Carmine with Acidic Bromate
Jonnalagadda, Sreekantha B.,Simoyi, Reuben,Muthakia, Gerald K.
, p. 1111 - 1116 (2007/10/02)
The oxidation kinetics of indigo carmine (disodium 3,3'-dioxobi-indolin-2,2'-ylidene-5,5'-disulphonate) with potassium bromate have been studied in aqueous sulphuric acid, by monitoring the absorbance of indigo carmine (IC) at 610 nm.The reaction involves competitive and consecutive reaction steps-an initial slow step followed by rapid one for depletion of IC.For the initial stages the reaction order is four-first-order with respect to IC and bromate ion and second order with H+ ion.For the fast reaction step the studies are limited to qualitative treatment due to the complex nature of the reaction.The rate of depleption of IC increased with time and with the increase in HOBr concentration.Hypobromous acid, the reaction intermediate, may possibly compete with bromate ion for IC to give an intermediate, which is further oxidised to yield the final product, isatin-5-monosulphonic acid.The stoicheiometric ratio of IC to bromate is 3:2.The dual role of bromine ion as an inhibitor and autocatalyst in the reaction mechanism is discussed.Computer simulations were performed using the proposed mechanism.The results of the computer simulations are similar to the experimental observations.
Derivatives of Isatin in Aqueous Solution. I. Kinetics of Ring Opening of Isatin-5-sulfonate
Stuenzi, Hans
, p. 365 - 371 (2007/10/02)
The reactions of isatin-5-sulfonate anion (si-) which cause a hysteresis in pH titrations were studied by pH-metric and n.m.r. spectroscopic methods.Rapid alkalimetric titrations gave the pKa value corresponding to the addition of OH%& to si- a(ring) 9.55>.The slow ring opening to the sulfonatoisatate dianion (sia2-) led to a drift of the pH values towards an equilibrium buffer region.Its pKa value a(eq) 3.44> corresponds to the reaction si- + H2Osia2- + H+.Rapid back-titration gave the pKa value of the ring-opened species Hsia- a(open) c. 1.3>.The rate law for the ring opening d/dt = k2(OH) + k1 + k1* was obtained from the rate of change of pH.N-Methylisatin-5-sulfonate behaves analogously.
